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FKBP52 Antibody - Primary antibody, specific to FKBP52, Rabbit IgG

  • Carrier Free
  • ExactAb™
  • High performance
  • Validated
  • Lot by Lot
Features and benefits
  • Short Overview:

    pAb; Rabbit anti Human FKBP52 Antibody; WB, IHC; Unconjugated

  • Species reactivity(Reacts with): Human,Pig
  • Isotype: Rabbit IgG
    Application:
  • IHC
  • WB
Item Number
Ab103696
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab103696-10μl
10μl
In stock
$66.90
Ab103696-20μl
20μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$99.90
Ab103696-50μl
50μl
In stock
$199.90
Ab103696-100μl
100μl
In stock
$289.90
Ab103696-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,699.90

pAb; Rabbit anti Human FKBP52 Antibody; WB, IHC; Unconjugated

Basic Description

Product NameFKBP52 Antibody - Primary antibody, specific to FKBP52, Rabbit IgG
Synonyms51 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; EC 5.2.1.8; FK506 binding protein 4, 59kDa; FK506-binding protein 4 (59kD); FK506-binding protein 4; FKBP4; FKBP-4; FKBP51; FKBP52; FKBP-52; FKBP52T-cell FK506-binding protein, 59kD; FKBP59;
Specifications & PurityExactAb™, Validated, Carrier Free, High performance, Lot by Lot
Host speciesRabbit
SpecificityFKBP52
ImmunogenRecombinant FKBP4 expressed in E.coli (AA 2-459).
Positive ControlWB: Recombinant Human FKBP4; K562, Porcine cerebrum and Porcine kidney lysates. IHC: Human stomach, prostate cancer, cerebrum, colorectal cancer, liver and lung cancer tissues.
ConjugationUnconjugated
GradeCarrier Free, ExactAb™, High performance, Validated
Product Description

Rabbit anti Human FKBP52 Antibody, Polyclonal, could be used for WB, IHC and so on.
Application
WB: 0.01-3 µg/mL
IHC: 5-30 μg/mL
Protein Function
Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unliganded steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly.

Product Properties

IsotypeRabbit IgG
SDS-PAGE150 kDa
Purification MethodAntigen affinity purified + Protein A purified
FormLiquid
ConcentrationLot by Lot
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Associated Targets

FKBP4 Tchem Peptidyl-prolyl cis-trans isomerase FKBP4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Application

ApplicationDilution info
IHC

5-30 µg/mL

WB

0.01-3 µg/mL

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot NumberCertificate TypeDateItem
ZJ24F0505952Certificate of AnalysisMay 22, 2024 Ab103696
ZJ24F0505953Certificate of AnalysisMay 22, 2024 Ab103696
ZJ24F0505954Certificate of AnalysisMay 22, 2024 Ab103696

Related Documents

References

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2. Bruner KL, Derfoul A, Robertson NM, Guerriero G, Fernandes-Alnemri T, Alnemri ES, Litwack G.  (1997)  The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52..  Recept Signal Transduct,  (2): (85-98).  [PMID:9392437]
3. Francis Impens,Lilliana Radoshevich,Pascale Cossart,David Ribet.  (2014-08-13)  Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli..  Proceedings of the National Academy of Sciences of the United States of America,  111  ((34)): (12432-12437).  [PMID:25114211]
4. Sharon Gauci,Andreas O Helbig,Monique Slijper,Jeroen Krijgsveld,Albert J R Heck,Shabaz Mohammed.  (2009-05-06)  Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach..  Analytical chemistry,  81  ((11)): (4493-4501).  [PMID:19413330]
5. Li Q, Moutiez M, Charbonnier JB, Vaudry K, Ménez A, Quéméneur E, Dugave C..  (2000)  Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs..  J Med Chem,  43  (9): (1770-1779).  [PMID:10794694]
6. Demange L, Moutiez M, Dugave C..  (2002)  Synthesis and evaluation of Glypsi(PO(2)R-N)Pro-containing pseudopeptides as novel inhibitors of the human cyclophilin hCyp-18..  J Med Chem,  45  (18): (3928-3933).  [PMID:12190314]
7. Zhao L, Huang W, Liu H, Wang L, Zhong W, Xiao J, Hu Y, Li S..  (2006)  FK506-binding protein ligands: structure-based design, synthesis, and neurotrophic/neuroprotective properties of substituted 5,5-dimethyl-2-(4-thiazolidine)carboxylates..  J Med Chem,  49  (14): (4059-4071).  [PMID:16821768]
8. Zhao L, Liu H, Wang L, Li S..  (2006)  Modeling and synthesis of non-cyclic derivatives of GPI-1046 as potential FKBP ligands with neurotrophic properties..  Bioorg Med Chem Lett,  16  (16): (4385-4390).  [PMID:16753298]
9. Gopalakrishnan R, Kozany C, Gaali S, Kress C, Hoogeland B, Bracher A, Hausch F..  (2012)  Evaluation of synthetic FK506 analogues as ligands for the FK506-binding proteins 51 and 52..  J Med Chem,  55  (9): (4114-4122).  [PMID:22455444]
10. Feng X, Sippel C, Knaup FH, Bracher A, Staibano S, Romano MF, Hausch F..  (2020)  A Novel Decalin-Based Bicyclic Scaffold for FKBP51-Selective Ligands..  J Med Chem,  63  (1): (231-240).  [PMID:31800244]
11. de la Sierra-Gallay IL, Belnou M, Chambraud B, Genet M, van Tilbeurgh H, Aumont-Nicaise M, Desmadril M, Baulieu EE, Jacquot Y, Byrne C..  (2020)  Bioinspired Hybrid Fluorescent Ligands for the FK1 Domain of FKBP52..  J Med Chem,  63  (18): (10330-10338).  [PMID:32866001]
12. Bauder M, Meyners C, Purder PL, Merz S, Sugiarto WO, Voll AM, Heymann T, Hausch F..  (2021)  Structure-Based Design of High-Affinity Macrocyclic FKBP51 Inhibitors..  J Med Chem,  64  (6.0): (3320-3349).  [PMID:33666419]
13. Peattie, D A DA and 6 more authors..  (1992)  Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes..  Proceedings of the National Academy of Sciences of the United States of America,    (15):   [PMID:1279700]
14. Yem, A W AW and 6 more authors..  (1992)  The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13..  The Journal of biological chemistry,    (15):   [PMID:1371107]
15. Tai, P K PK, Albers, M W MW, Chang, H H, Faber, L E LE and Schreiber, S L SL..  (1992)  Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex..  Science (New York, N.Y.),    (29):   [PMID:1376003]
16. Wiederrecht, G G and 9 more authors..  (1992)  Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex..  The Journal of biological chemistry,    (25):   [PMID:1383226]
17. Sanchez, E R ER, Faber, L E LE, Henzel, W J WJ and Pratt, W B WB..  (1990)  The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins..  Biochemistry,    (29):   [PMID:2378870]
18. Guo, Y Y and 7 more authors..  (2001)  Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex..  The Journal of biological chemistry,    (7):   [PMID:11583998]
19. Krummrei, Ulrike U, Baulieu, Etienne-Emile EE and Chambraud, Béatrice B..  (2003)  The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis..  Proceedings of the National Academy of Sciences of the United States of America,    (4):   [PMID:12604780]
20. Wu, Beili B and 9 more authors..  (2004)  3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex..  Proceedings of the National Academy of Sciences of the United States of America,    (1):   [PMID:15159550]
21. Scherer, Steven E SE and 216 more authors..  (2006)  The finished DNA sequence of human chromosome 12..  Nature,    (16):   [PMID:16541075]
22. Beausoleil, Sean A SA, Villén, Judit J, Gerber, Scott A SA, Rush, John J and Gygi, Steven P SP..  (2006)  A probability-based approach for high-throughput protein phosphorylation analysis and site localization..  Nature biotechnology,      [PMID:16964243]
23. Matsuoka, Shuhei S and 12 more authors..  (2007)  ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage..  Science (New York, N.Y.),    (25):   [PMID:17525332]
24. Dephoure, Noah N and 6 more authors..  (2008)  A quantitative atlas of mitotic phosphorylation..  Proceedings of the National Academy of Sciences of the United States of America,    (5):   [PMID:18669648]
25. Shim, Sangwoo S and 9 more authors..  (2009)  Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening..  Neuron,    (25):   [PMID:19945390]
26. Shimamoto, Seiko S, Kubota, Yasuo Y, Tokumitsu, Hiroshi H and Kobayashi, Ryoji R..  (2010)  S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats..  FEBS letters,    (19):   [PMID:20188096]
27. Rigbolt, Kristoffer T G KT and 9 more authors..  (2011)  System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation..  Science signaling,    (15):   [PMID:21406692]
28. Gallo, Luciana I LI, Lagadari, Mariana M, Piwien-Pilipuk, Graciela G and Galigniana, Mario D MD..  (2011)  The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress..  The Journal of biological chemistry,    (26):   [PMID:21730050]
29. Zhou, Houjiang H and 6 more authors..  (2013)  Toward a comprehensive characterization of a human cancer cell phosphoproteome..  Journal of proteome research,    (4):   [PMID:23186163]

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