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Flanvotumab (anti-TYRP1) - Primary antibody, specific to TYRP1, >95%, high purity, Human IgG1, OTHER of 5,6-dihydroxyindole-2-carboxylic acid oxidase other

  • Azide Free
  • Carrier Free
  • ExactAb™
  • Low Endotoxin
  • Recombinant
  • Validated
  • ≥95%(SDS-PAGE&SEC)
  • Lot by Lot
Features and benefits
  • Short Overview:

    Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

  • Species reactivity(Reacts with): Human,Mouse
  • Isotype: Human IgG1
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
Item Number
Ab176073
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab176073-100μg
100μg
In stock
$59.90
Ab176073-1mg
1mg
In stock
$289.90
Ab176073-5mg
5mg
In stock
$749.90
Ab176073-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,189.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Accession#:P17643 Gene ID:7306 TYRP1

Basic Description

Product NameFlanvotumab (anti-TYRP1) - Primary antibody, specific to TYRP1, >95%, high purity, Human IgG1
Synonyms5 antibody; 5,6 dihydroxyindole 2 carboxylic acid oxidase antibody; 6-dihydroxyindole-2-carboxylic acid oxidase antibody; b-PROTEIN antibody; CAS2 antibody; Catalase B antibody; CATB antibody; DHICA oxidase antibody; Glycoprotein 75 antibody; GP75 antibod
Specifications & PurityExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
SpecificityTYRP1
ConjugationUnconjugated
GradeAzide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action TypeOTHER
Mechanism of actionOTHER of 5,6-dihydroxyindole-2-carboxylic acid oxidase other
Product Description

Flanvotumab (anti-TYRP1) is a human monoclonal antibody targeting to tyrosinase-related protein (TYRP1), specifically expressed in melanocytes and melanoma cells. Flanvotumab (anti-TYRP1) acts function via natural killing-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). Flanvotumab (anti-TYRP1) has potent anti-tumor activity and good tolerance.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

IsotypeHuman IgG1
Light Chain Typekappa
SDS-PAGE26.8 kDa (Light Chain) & 51.0 kDa (Heavy Chain), under reducing conditions; 171.0 kDa, under non-reducing conditions.
Purification MethodProtein A purified
Purity>95%
FormLiquid
ConcentrationLot by Lot
Storage TempStore at -80°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS1188277-05-5

Images

Flanvotumab (anti-TYRP1) (Ab176073) - SEC
The purity of Flanvotumab (anti-TYRP1) (Ab176073) is more than 95% verified by HPLC.

Associated Targets

TYRP1 Tbio 5,6-dihydroxyindole-2-carboxylic acid oxidase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot NumberCertificate TypeDateItem
ZJ24F0202867Certificate of AnalysisFeb 23, 2024 Ab176073
ZJ24F0202868Certificate of AnalysisFeb 23, 2024 Ab176073
ZJ24F0202866Certificate of AnalysisFeb 23, 2024 Ab176073

Related Documents

References

1. Shibata, K K, Takeda, K K, Tomita, Y Y, Tagami, H H and Shibahara, S S..  (1992)  Downstream region of the human tyrosinase-related protein gene enhances its promoter activity..  Biochemical and biophysical research communications,    (30):   [PMID:1575733]
2. Halaban, R R and Moellmann, G G..  (1990)  Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity..  Proceedings of the National Academy of Sciences of the United States of America,      [PMID:1693779]
3. Chintamaneni, C D CD and 5 more authors..  (1991)  Mapping the human CAS2 gene, the homologue of the mouse brown (b) locus, to human chromosome 9p22-pter..  Biochemical and biophysical research communications,    (15):   [PMID:1906272]
4. and Urquhart, A A..  (1991)  Human tyrosinase-like protein (TYRL) carboxy terminus: closer homology with the mouse protein than previously reported..  Nucleic acids research,    (25):   [PMID:1945866]
5. Cohen, T T, Muller, R M RM, Tomita, Y Y and Shibahara, S S..  (1990)  Nucleotide sequence of the cDNA encoding human tyrosinase-related protein..  Nucleic acids research,    (11):   [PMID:2111010]
6. Vijayasaradhi, S S, Bouchard, B B and Houghton, A N AN..  (1990)  The melanoma antigen gp75 is the human homologue of the mouse b (brown) locus gene product..  The Journal of experimental medicine,    (1):   [PMID:2324688]
7. Sturm, R A RA and 7 more authors..  (1995)  Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family..  Genomics,    (1):   [PMID:8530077]
8. Box, N F NF and 5 more authors..  (1998)  Complete sequence and polymorphism study of the human TYRP1 gene encoding tyrosinase-related protein 1..  Mammalian genome : official journal of the International Mammalian Genome Society,      [PMID:9434945]
9. Boissy, R E RE, Sakai, C C, Zhao, H H, Kobayashi, T T and Hearing, V J VJ..  (1998)  Human tyrosinase related protein-1 (TRP-1) does not function as a DHICA oxidase activity in contrast to murine TRP-1..  Experimental dermatology,      [PMID:9758418]
10. Basrur, Venkatesha V and 12 more authors..  ()  Proteomic analysis of early melanosomes: identification of novel melanosomal proteins..  Journal of proteome research,      [PMID:12643545]
11. Rooryck, Caroline C, Roudaut, Christel C, Robine, Eulalie E, Müsebeck, Jörg J and Arveiler, Benoît B..  (2006)  Oculocutaneous albinism with TYRP1 gene mutations in a Caucasian patient..  Pigment cell research,      [PMID:16704458]
12. Chi, An A and 16 more authors..  (2006)  Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes..  Journal of proteome research,      [PMID:17081065]
13. Kenny, Eimear E EE and 10 more authors..  (2012)  Melanesian blond hair is caused by an amino acid change in TYRP1..  Science (New York, N.Y.),    (4):   [PMID:22556244]
14. Simeonov, Dimitre R DR and 15 more authors..  (2013)  DNA variations in oculocutaneous albinism: an updated mutation list and current outstanding issues in molecular diagnostics..  Human mutation,      [PMID:23504663]
15. Lai, Xuelei; Wichers, Harry J; Soler-Lopez, Montserrat and Dijkstra, Bauke W..  (2017)  Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis..  Angewandte Chemie (International ed. in English),    (7):   [PMID:28661582]

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