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Flanvotumab (anti-TYRP1) (Ab176073) - SEC
The purity of Flanvotumab (anti-TYRP1) (Ab176073) is more than 95% verified by HPLC.
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
Ab176073-100μg | 100μg | In stock | $59.90 | |
Ab176073-1mg | 1mg | In stock | $289.90 | |
Ab176073-5mg | 5mg | In stock | $749.90 | |
Ab176073-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,189.90 |
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
Product Name | Flanvotumab (anti-TYRP1) - Primary antibody, specific to TYRP1, >95%, high purity, Human IgG1 |
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Synonyms | 5 antibody; 5,6 dihydroxyindole 2 carboxylic acid oxidase antibody; 6-dihydroxyindole-2-carboxylic acid oxidase antibody; b-PROTEIN antibody; CAS2 antibody; Catalase B antibody; CATB antibody; DHICA oxidase antibody; Glycoprotein 75 antibody; GP75 antibod |
Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot |
Specificity | TYRP1 |
Conjugation | Unconjugated |
Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
Action Type | OTHER |
Mechanism of action | OTHER of 5,6-dihydroxyindole-2-carboxylic acid oxidase other |
Product Description | Flanvotumab (anti-TYRP1) is a human monoclonal antibody targeting to tyrosinase-related protein (TYRP1), specifically expressed in melanocytes and melanoma cells. Flanvotumab (anti-TYRP1) acts function via natural killing-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). Flanvotumab (anti-TYRP1) has potent anti-tumor activity and good tolerance. |
Isotype | Human IgG1 |
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Light Chain Type | kappa |
SDS-PAGE | 26.8 kDa (Light Chain) & 51.0 kDa (Heavy Chain), under reducing conditions; 171.0 kDa, under non-reducing conditions. |
Purification Method | Protein A purified |
Purity | >95% |
Form | Liquid |
Concentration | Lot by Lot |
Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
Shipped In | Ice chest + Ice pads |
Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
CAS | 1188277-05-5 |
Flanvotumab (anti-TYRP1) (Ab176073) - SEC
The purity of Flanvotumab (anti-TYRP1) (Ab176073) is more than 95% verified by HPLC.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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ZJ24F0202867 | Certificate of Analysis | Feb 23, 2024 | Ab176073 |
ZJ24F0202868 | Certificate of Analysis | Feb 23, 2024 | Ab176073 |
ZJ24F0202866 | Certificate of Analysis | Feb 23, 2024 | Ab176073 |
1. Shibata, K K, Takeda, K K, Tomita, Y Y, Tagami, H H and Shibahara, S S.. (1992) Downstream region of the human tyrosinase-related protein gene enhances its promoter activity.. Biochemical and biophysical research communications, (30): [PMID:1575733] |
2. Halaban, R R and Moellmann, G G.. (1990) Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:1693779] |
3. Chintamaneni, C D CD and 5 more authors.. (1991) Mapping the human CAS2 gene, the homologue of the mouse brown (b) locus, to human chromosome 9p22-pter.. Biochemical and biophysical research communications, (15): [PMID:1906272] |
4. and Urquhart, A A.. (1991) Human tyrosinase-like protein (TYRL) carboxy terminus: closer homology with the mouse protein than previously reported.. Nucleic acids research, (25): [PMID:1945866] |
5. Cohen, T T, Muller, R M RM, Tomita, Y Y and Shibahara, S S.. (1990) Nucleotide sequence of the cDNA encoding human tyrosinase-related protein.. Nucleic acids research, (11): [PMID:2111010] |
6. Vijayasaradhi, S S, Bouchard, B B and Houghton, A N AN.. (1990) The melanoma antigen gp75 is the human homologue of the mouse b (brown) locus gene product.. The Journal of experimental medicine, (1): [PMID:2324688] |
7. Sturm, R A RA and 7 more authors.. (1995) Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family.. Genomics, (1): [PMID:8530077] |
8. Box, N F NF and 5 more authors.. (1998) Complete sequence and polymorphism study of the human TYRP1 gene encoding tyrosinase-related protein 1.. Mammalian genome : official journal of the International Mammalian Genome Society, [PMID:9434945] |
9. Boissy, R E RE, Sakai, C C, Zhao, H H, Kobayashi, T T and Hearing, V J VJ.. (1998) Human tyrosinase related protein-1 (TRP-1) does not function as a DHICA oxidase activity in contrast to murine TRP-1.. Experimental dermatology, [PMID:9758418] |
10. Basrur, Venkatesha V and 12 more authors.. () Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.. Journal of proteome research, [PMID:12643545] |
11. Rooryck, Caroline C, Roudaut, Christel C, Robine, Eulalie E, Müsebeck, Jörg J and Arveiler, Benoît B.. (2006) Oculocutaneous albinism with TYRP1 gene mutations in a Caucasian patient.. Pigment cell research, [PMID:16704458] |
12. Chi, An A and 16 more authors.. (2006) Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.. Journal of proteome research, [PMID:17081065] |
13. Kenny, Eimear E EE and 10 more authors.. (2012) Melanesian blond hair is caused by an amino acid change in TYRP1.. Science (New York, N.Y.), (4): [PMID:22556244] |
14. Simeonov, Dimitre R DR and 15 more authors.. (2013) DNA variations in oculocutaneous albinism: an updated mutation list and current outstanding issues in molecular diagnostics.. Human mutation, [PMID:23504663] |
15. Lai, Xuelei; Wichers, Harry J; Soler-Lopez, Montserrat and Dijkstra, Bauke W.. (2017) Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.. Angewandte Chemie (International ed. in English), (7): [PMID:28661582] |