Grouped product items

SKU

Size

Availability

Price

Qty

F336171-1mg

1mg

Available within 8-12 weeks(?)

$58.90

F336171-10mg

10mg

Available within 4-8 weeks(?)

$484.90

Basic Description

Synonyms	fluprostenol\|travoprost acid\|(+)-fluprostenol\|54276-17-4\|Fluprostenol, (+)-\|40666-16-8\|travoprost free acid\|Fluprostenolum\|ICI 81,008\|Fluoprostenol\|EINECS 255-029-3\|AL-5848\|CHEBI:60782\|(+/-)-Fluprostenol\|MEH3MCE8X1\|(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E
Specifications & Purity	Moligand™, ≥98%, Solution in ethanol (10 mg/ml)
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of EP 3 receptor;Agonist of FP receptor;Agonist of TP receptor
Product Description	Fluprostenol is a PGF\|2α\|R (prostaglandin F (FP) receptor) agonist that is more selective than PGF\|2α\|. The compound can activate phosphorylation of ERK 2 (extracellular signal-regulated kinase (ERK)), p38-Mitogen-activated protein kinase (MAPK) and JNK\|3\|(c-Jun N-terminal kinase (JNK)) in rat aortas. Studies have shown that it can induce phospholipase C and Ca\|+\|mobilization in human myometrial cells and can decrease intraocular pressure (IOP) by improving aqueous humor outflow through the trabecular meshwork (TM) via inhibition of endothelin (ET)-1-dependent mechanisms. Fluprostenol also suppresses the expression of adipogenic genes in 3T3-L1 cells.

Product Properties

pKa	pKa: 4.76

Associated Targets

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

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CSNK1D Tchem Casein kinase I isoform delta 0 Activities

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TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

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PTGFR Tclin Prostaglandin F2-alpha receptor 2 Activities

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PTGIR Tclin Prostacyclin receptor 0 Activities

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PTGER3 Tclin Prostaglandin E2 receptor EP3 subtype 1 Activities

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BRPF1 Tchem Peregrin 0 Activities

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AURKA Tchem Aurora kinase A 0 Activities

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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

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ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

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TBXA2R Tclin Thromboxane A2 receptor 1 Activities

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GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Discover Target: MAPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoic acid
INCHI	InChI=1S/C23H29F3O6/c24-23(25,26)15-6-5-7-17(12-15)32-14-16(27)10-11-19-18(20(28)13-21(19)29)8-3-1-2-4-9-22(30)31/h1,3,5-7,10-12,16,18-21,27-29H,2,4,8-9,13-14H2,(H,30,31)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m1/s1
InChi Key	WWSWYXNVCBLWNZ-QIZQQNKQSA-N
Canonical SMILES	C1C(C(C(C1O)C=CC(COC2=CC=CC(=C2)C(F)(F)F)O)CC=CCCCC(=O)O)O
Isomeric SMILES	C1[C@@H]([C@@H]([C@H]([C@@H]1O)/C=C/[C@H](COC2=CC=CC(=C2)C(F)(F)F)O)C/C=C\CCCC(=O)O)O
WGK Germany	1
PubChem CID	5311100
Molecular Weight	458.47

Database links

PubChem CID	5311100
CAS Registry No.	40666-16-8
ChEMBL Ligand	CHEMBL1201379
GPCRdb Ligand	fluprostenol

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	Soluble in ethanol (1 mg/100μL), acetone, and methanol.
Refractive Index	1.575
Boil Point(°C)	608° C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08, GHS07
Signal	Danger
Hazard Statements	H302:Harmful if swallowed H300:Fatal if swallowed H310:Fatal in contact with skin H330:Fatal if inhaled H372:Causes damage to organs through prolonged or repeated exposure H370:Causes damage to organs H300+H310+H330:Fatal if swallowed, in contact with skin or if inhaled
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P262:Do not get in eyes, on skin, or on clothing. P320:Specific treatment is urgent (see ... on this label). P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P301+P317:IF SWALLOWED: Get medical help. P308+P316:IF exposed or concerned: Get emergency medical help immediately. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell.
WGK Germany	1

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Fluprostenol - Solution in ethanol (10 mg/ml),98%, high purity , CAS No.40666-16-8, Agonist of EP 3 receptor;Agonist of FP receptor;Agonist of TP receptor