| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| F336070-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $839.90 |
a pentadeuterated form of fluticasone propionate
| Synonyms | [(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] 2,2,3,3,3-pentadeuteriopropanoate | DTXSID501101416 | SS-4490 | AKOS025311 |
|---|---|
| Specifications & Purity | ≥92%,≥95atom%D |
| Storage Temp | Store at 2-8°C |
| Shipped In | Wet ice |
| Product Description | Fluticasone propionate-d5 is the labeled form of fluticasone propionate . Fluticasone propionate is a high affinity, selective glucocorticoid receptor (GR) agonist (K|d|= 0.5 nM). Fluticasone propionate potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC|50|= 3.7 nM)|in vitro|. Fluticasone propionate is a lipophilic anti-inflammatory agent derived from flumethasone . |
| IUPAC Name | [(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] 2,2,3,3,3-pentadeuteriopropanoate |
|---|---|
| INCHI | InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1/i1D3,5D2 |
| InChi Key | WMWTYOKRWGGJOA-AMTWIDTLSA-N |
| Canonical SMILES | CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF |
| Isomeric SMILES | [2H]C([2H])([2H])C([2H])([2H])C(=O)O[C@@]1([C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O)C)C)C(=O)SCF |
| Alternate CAS | 80474-14-2（unlabelled） |
| PubChem CID | 91820603 |
| Molecular Weight | 505.61 |
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| Solubility | Soluble in chloroform, ethyl acetate, and dichloromethane(Sparingly). |
|---|---|
| Refractive Index | n20D1.56 (Predicted) |
| Boil Point(°C) | 568.3° C |
| Melt Point(°C) | 265-267° C (dec.) |
| Pictogram(s) | GHS08, GHS09, GHS07 |
|---|---|
| Signal | Danger |
| Hazard Statements | H373:Causes damage to organs through prolonged or repeated exposure H413:May cause long lasting harmful effects to aquatic life H302:Harmful if swallowed H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H410:Very toxic to aquatic life with long lasting effects H360:May damage fertility or the unborn child H361:Suspected of damaging fertility or the unborn child |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately. |
