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Fluxametamide - 98%, high purity , CAS No.928783-29-3

  • ≥98%
Item Number
F646301
Grouped product items
SKUSizeAvailabilityPrice Qty
F646301-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$100.90
F646301-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$159.90
F646301-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$544.90

Basic Description

Specifications & Purity≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Fluxametamide is an insecticide with wide spectrum, acts as an antagonist of GABA- and glutamate-gated chloride channels , with IC 50 of 1.95 nM and 225 nM for M. domestica GABACls and GluCls.

In Vitro

Fluxametamide is an antagonist of GABA- and glutamate-gated chloride channels, dose-dependently inhibits currents induced by GABA and glutamate in M. domestica GABACls and GluCls, with IC 50 values of 1.95 (1.18-3.21) nM and 225 (137-372) nM, respectively, and displays potent antagonistic activity against T. urticae GABACls with an IC 50 of 0.219 (0.127-0.381) nM. Fluxametamide inhibits GABA responses in the wild-type L. striatellus GABACls with IC 50 values of 1.40 (0.57-3.29) nM; in the A2′N mutant GABACls, the IC 50 value is 3.51 (2.17-5.69) nM. Moreover, Fluxametamide scarcely inhibits GABA (EC 50 )-induced currents in rat GABACls at 10 μM and with no inhibition on glycine (EC 50 )-induced current in human α1 GlyCls at tested concentrations. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fluxametamide shows significant insecticidal activity with an LD 50 (LD 95 ) value of 12.9 ± 4.9 ng/fly (38.7 ± 6.3 ng/fly) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 1.95 nM ( M. domestica GABACls), 225 nM ( M. domestica GluCls)

Names and Identifiers

Canonical SMILES CC1=C(C=CC(=C1)C2=NOC(C2)(C3=CC(=CC(=C3)Cl)Cl)C(F)(F)F)C(=O)N/C=N\OC
Isomeric SMILES CC1=C(C=CC(=C1)C2=NOC(C2)(C3=CC(=CC(=C3)Cl)Cl)C(F)(F)F)C(=O)N/C=N\OC
PubChem CID 135927338
Molecular Weight 474.26

Certificates

C of A & Other Certificates

Chemical and Physical Properties

SolubilityDMSO : 125 mg/mL (263.57 mM; Need ultrasonic)

Related Documents

Solution Calculators