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Folinic acid - 99%, high purity , CAS No.58-05-9

Moligand™

≥99%

CAS#: 58-05-9
Formula: C₂₀H₂₃N₇O₇
Molecular Weight: 473.44
EC Number: 216-082-8,200-361-6,846-741-0
PubChem CID: 135403648

Item Number

F413332

Grouped product items
SKU	Size	Availability	Price
F413332-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$2,925.90
F413332-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$10,530.90
F413332-5g	5g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$47,385.90

Thymidylate Synthase Inhibitors

Basic Description

Synonyms	folinic acid \| leucovorin \| 5-Formyltetrahydrofolic acid \| folinate \| 58-05-9 \| Welcovorin \| Leucal \| Acide folinique \| Folinic acid-SF \| Leucoverin \| 5-Formyl-5,6,7,8-tetrahydrofolic acid \| N5-Formyltetrahydrofolic acid \| UNII-Q573I9DVLP \| Q573I9DVLP \| 5-formyltetrahydrofolate \| CHEB
Specifications & Purity	99%
Storage Temp	Protected from light,Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	Information Folinic acid Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS) . Targets Thymidylate Synthase

pKa

pKₐ: 0.99 (Predicted), pKₐ: 3.1, pKₐ: 2.8, pKₐ: 10.4, pKₐ: 9.74 (Predicted)

Ki Data

Dihydrofolate reductase: Ki= 2.37 μM (human); CEM: Ki= 0.74 μM (human)

Names and Identifiers

IUPAC Name	(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
INCHI	InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1
InChi Key	VVIAGPKUTFNRDU-ABLWVSNPSA-N
Canonical SMILES	C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Isomeric SMILES	C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Alternate CAS	58-05-9,1492-18-8,41927-89-3,6035-45-6 (calcium (1:1) salt,penta-hydrate)
PubChem CID	135403648
MeSH Entry Terms	5 Formyltetrahydrofolate;5 Formyltetrahydropteroylglutamate;5-Formyltetrahydrofolate;5-Formyltetrahydropteroylglutamate;Acid, Folinic;Calcium Folinate;Calcium Leucovorin;Citrovorum Factor;Factor, Citrovorum;Folinate, Calcium;Folinic Acid;Folinic Acid SF;F
Molecular Weight	473.44

Wikipedia

DrugBank Ligand

PubChem CID

ChEMBL Ligand

CAS Registry No.

ChEBI

DrugCentral Ligand

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
G2230350	Certificate of Analysis	Jun 08, 2022	F413332
G2230351	Certificate of Analysis	Jun 08, 2022	F413332
G2230352	Certificate of Analysis	Jun 08, 2022	F413332
G2230460	Certificate of Analysis	Jun 08, 2022	F413332
G2230461	Certificate of Analysis	Jun 08, 2022	F413332

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 95 mg/mL (200.65 mM); Water: Insoluble; Ethanol: Insoluble;
Sensitivity	Light sensitive
Refractive Index	n20D1.75 (Predicted)
Specific Rotation[α]	α25/D +16.76°, c = 3.5 in 5% sodium carbonate; α21/D +14.9°, c = 1 in water; α20/D -15.1° , c = 1.82; α 20/D +14.26°
Melt Point(°C)	240-250° C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P342+P311:IF experiencing respiratory symptoms: Call a POISON CENTER/doctor/... P302+P352:IF ON SKIN: wash with plenty of water. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P337+P313:IF eye irritation persists: Get medical advice/attention. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P304+P340+P312: IF INHALED: Remove person to fresh air and keep comfortable for breathing.Call a POISON CENTER or doctor. if you feel unwell.

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Folinic acid - 99%, high purity , CAS No.58-05-9

Basic Description

Product Properties

Names and Identifiers

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