Basic Description

Synonyms	folinic acid \| leucovorin \| 5-Formyltetrahydrofolic acid \| folinate \| 58-05-9 \| Welcovorin \| Leucal \| Acide folinique \| Folinic acid-SF \| Leucoverin \| 5-Formyl-5,6,7,8-tetrahydrofolic acid \| N5-Formyltetrahydrofolic acid \| UNII-Q573I9DVLP \| Q573I9DVLP \| 5-formyltetrahydrofolate \| CHEB
Specifications & Purity	10mM in DMSO
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	Information Folinic acid Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS) . Targets Thymidylate Synthase

Product Properties

pKa	pKₐ: 0.99 (Predicted), pKₐ: 3.1, pKₐ: 2.8, pKₐ: 10.4, pKₐ: 9.74 (Predicted)
Ki Data	Dihydrofolate reductase: Ki= 2.37 μM (human); CEM: Ki= 0.74 μM (human)

IUPAC Name	(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
INCHI	InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1
InChi Key	VVIAGPKUTFNRDU-ABLWVSNPSA-N
Canonical SMILES	C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Isomeric SMILES	C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Alternate CAS	58-05-9,1492-18-8,41927-89-3,6035-45-6 (calcium (1:1) salt,penta-hydrate)
PubChem CID	135403648
MeSH Entry Terms	5 Formyltetrahydrofolate;5 Formyltetrahydropteroylglutamate;5-Formyltetrahydrofolate;5-Formyltetrahydropteroylglutamate;Acid, Folinic;Calcium Folinate;Calcium Leucovorin;Citrovorum Factor;Factor, Citrovorum;Folinate, Calcium;Folinic Acid;Folinic Acid SF;F
Molecular Weight	473.44

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Refractive Index	n20D1.75 (Predicted)
Specific Rotation[α]	α25/D +16.76°, c = 3.5 in 5% sodium carbonate; α21/D +14.9°, c = 1 in water; α20/D -15.1° , c = 1.82; α 20/D +14.26°
Melt Point(°C)	240-250° C

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P342+P311:IF experiencing respiratory symptoms: Call a POISON CENTER/doctor/... P302+P352:IF ON SKIN: wash with plenty of water. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P337+P313:IF eye irritation persists: Get medical advice/attention. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P304+P340+P312: IF INHALED: Remove person to fresh air and keep comfortable for breathing.Call a POISON CENTER or doctor. if you feel unwell.

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