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Fulranumab (anti-NGF) (Ab175829) - SEC
The purity of Fulranumab (anti-NGF) (Ab175829) is more than 95% verified by HPLC.
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
Ab175829-100μg | 100μg | In stock | $69.90 | |
Ab175829-1mg | 1mg | In stock | $327.90 | |
Ab175829-5mg | 5mg | In stock | $807.90 | |
Ab175829-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,287.90 |
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
Product Name | Fulranumab (anti-NGF) - Primary antibody, specific to NGF, >95%, high purity, Human IgG2 |
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Synonyms | Beta nerve growth factor antibody; Beta NGF antibody; Beta-nerve growth factor antibody; Beta-NGF antibody; HSAN5 antibody; MGC161426 antibody; MGC161428 antibody; Nerve growth factor (beta polypeptide) antibody; Nerve growth factor antibody; Nerve growth |
Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot |
Specificity | NGF |
Conjugation | Unconjugated |
Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
Action Type | INHIBITOR |
Mechanism of action | INHIBITOR of Beta-nerve growth factor inhibitor |
Product Description | Fulranumab (anti-NGF) is a human IgG2 monoclonal antibody against nerve growth factor (NGF) and can be used for the research of pain. |
Isotype | Human IgG2 |
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Light Chain Type | kappa |
SDS-PAGE | 25.9 kDa (Light Chain) & 50.5 kDa (Heavy Chain), under reducing conditions; 167.6 kDa, under non-reducing conditions. |
Purification Method | Protein A purified |
Purity | >95% |
Form | Liquid |
Concentration | Lot by Lot |
Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
Shipped In | Ice chest + Ice pads |
Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
CAS | 902141-80-4 |
Fulranumab (anti-NGF) (Ab175829) - SEC
The purity of Fulranumab (anti-NGF) (Ab175829) is more than 95% verified by HPLC.
Fulranumab (anti-NGF) (Ab175829) - ELISA
Immobilized huNGFB at 2.0 μg/mL can bind Fulranumab (anti-NGF) (Ab175829) with the EC₅₀ of 15.96 ng/mL.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
ZJ24F0102646 | Certificate of Analysis | Jan 30, 2024 | Ab175829 |
ZJ24F0102645 | Certificate of Analysis | Jan 30, 2024 | Ab175829 |
ZJ24F0102644 | Certificate of Analysis | Jan 30, 2024 | Ab175829 |
1. Klein, R R, Jing, S Q SQ, Nanduri, V V, O'Rourke, E E and Barbacid, M M.. (1991) The trk proto-oncogene encodes a receptor for nerve growth factor.. Cell, (5): [PMID:1849459] |
2. Hallböök, F F, Ibáñez, C F CF and Persson, H H.. (1991) Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary.. Neuron, [PMID:2025430] |
3. Borsani, G G and 7 more authors.. (1990) cDNA sequence of human beta-NGF.. Nucleic acids research, (11): [PMID:2374737] |
4. Ullrich, A A, Gray, A A, Berman, C C, Coussens, L L and Dull, T J TJ.. (1983) Sequence homology of human and mouse beta-NGF subunit genes.. Cold Spring Harbor symposia on quantitative biology, [PMID:6327169] |
5. Ullrich, A A, Gray, A A, Berman, C C and Dull, T J TJ.. (1983) Human beta-nerve growth factor gene sequence highly homologous to that of mouse.. Nature, (30): [PMID:6688123] |
6. Tong, Y Y, Wang, H H and Chen, W W.. (1997) [Cloning and sequencing of the gene for premature beta nerve growth factor].. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, [PMID:10322959] |
7. Culmsee, C C, Semkova, I I and Krieglstein, J J.. (1999) NGF mediates the neuroprotective effect of the beta2-adrenoceptor agonist clenbuterol in vitro and in vivo: evidence from an NGF-antisense study.. Neurochemistry international, [PMID:10403429] |
8. Wiesmann, C C, Ultsch, M H MH, Bass, S H SH and de Vos, A M AM.. (1999) Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor.. Nature, (9): [PMID:10490030] |
9. Semkova, I I and Krieglstein, J J.. (1999) Neuroprotection mediated via neurotrophic factors and induction of neurotrophic factors.. Brain research. Brain research reviews, [PMID:10525174] |
10. Puls, I I and 5 more authors.. (1999) [Clenbuterol in amyotrophic lateral sclerosis. No indication for a positive effect].. Der Nervenarzt, [PMID:10637819] |
11. Riaz, S S SS and Tomlinson, D R DR.. (1999) Clenbuterol stimulates neurotrophic support in streptozotocin-diabetic rats.. Diabetes, obesity & metabolism, [PMID:11221812] |
12. Einarsdottir, Elisabet E and 8 more authors.. (2004) A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception.. Human molecular genetics, (15): [PMID:14976160] |
13. He, Xiao-Lin XL and Garcia, K Christopher KC.. (2004) Structure of nerve growth factor complexed with the shared neurotrophin receptor p75.. Science (New York, N.Y.), (7): [PMID:15131306] |
14. Wehrman, Tom T and 5 more authors.. (2007) Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors.. Neuron, (4): [PMID:17196528] |
15. Wijeyewickrema, Lakshmi C LC, Gardiner, Elizabeth E EE, Gladigau, Elsa L EL, Berndt, Michael C MC and Andrews, Robert K RK.. (2010) Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI.. The Journal of biological chemistry, (16): [PMID:20164177] |
16. Carvalho, Ofélia P OP and 8 more authors.. (2011) A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy.. Journal of medical genetics, [PMID:20978020] |
17. Davidson, G L G and 20 more authors.. (2012) Frequency of mutations in the genes associated with hereditary sensory and autonomic neuropathy in a UK cohort.. Journal of neurology, [PMID:22302274] |
18. Cao, Ziqin and 6 more authors.. (2020) Targeting nerve growth factor, a new option for treatment of osteoarthritis: a network meta-analysis of comparative efficacy and safety with traditional drugs.. Aging, (3): [PMID:33293475] |
19. Cargill, M M and 17 more authors.. (1999) Characterization of single-nucleotide polymorphisms in coding regions of human genes.. Nature genetics, [PMID:10391209] |