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G 418 disulfate salt - potency: ≥650 ug per mg, high purity , CAS No.108321-42-2

6 Citations
  • potency: ≥650 ug per mg
Item Number
G110917
Grouped product items
SKUSizeAvailabilityPrice Qty
G110917-250mg
250mg
In stock
$32.90
G110917-1g
1g
In stock
$99.90
G110917-5g
5g
In stock
$294.90
G110917-25g
25g
In stock
$1,325.90
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Aminoglycoside antibiotic agent

View related series
Anti-infection Antibiotic Bacterial Element classified compounds Glycoscience

Basic Description

SynonymsAC-32603 | G 418 disulfate salt | (2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid | C20H40N4O10.2H2SO4 | G
Specifications & Puritypotency: ≥650 ug per mg
Biochemical and Physiological MechanismsAminoglycoside antibiotic agent. Potent Delta7-SMN target sequence inducer. Inhibits amino acid incorporation into proteins. Shows cytotoxic effects. Inhibits the prokaryotic and eukaryotic elongation cycle. Shows antibacterial and antiprotozoal effects i
Storage TempStore at 2-8°C
Shipped InWet ice
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Names and Identifiers

Pubchem Sid488199327
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488199327
IUPAC Name (2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
INCHI InChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)/t6?,7-,8+,9+,10+,11-,12-,13-,14+,15+,16-,17-,18+,19-,20+;;/m0../s1
InChi Key UHEPSJJJMTWUCP-NKCAIAFTSA-N
Canonical SMILES CC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
Isomeric SMILES CC([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@H]3[C@H]([C@@H]([C@](CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
WGK Germany 3
PubChem CID 16218858
Molecular Weight 692.71

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

16 results found

Lot NumberCertificate TypeDateItem
B2105195Certificate of AnalysisDec 13, 2024 G110917
B2321790Certificate of AnalysisNov 11, 2022 G110917
B2321791Certificate of AnalysisNov 11, 2022 G110917
B2321792Certificate of AnalysisNov 11, 2022 G110917
B2321793Certificate of AnalysisNov 11, 2022 G110917
B2321794Certificate of AnalysisNov 11, 2022 G110917
B2321795Certificate of AnalysisNov 11, 2022 G110917
B2321986Certificate of AnalysisNov 11, 2022 G110917
I2222015Certificate of AnalysisSep 09, 2022 G110917
I2222256Certificate of AnalysisSep 09, 2022 G110917
J2430143Certificate of AnalysisSep 09, 2022 G110917
K2418066Certificate of AnalysisSep 09, 2022 G110917
H2205263Certificate of AnalysisJun 29, 2022 G110917
H2205264Certificate of AnalysisJun 29, 2022 G110917
H2205265Certificate of AnalysisJun 29, 2022 G110917
G1818123Certificate of AnalysisMay 09, 2022 G110917

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Chemical and Physical Properties

SensitivityHeat sensitive
Specific Rotation[α]111 ° (C=0.3, H2O)
Melt Point(°C)138-144°C

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Danger
Hazard Statements

H335:May cause respiratory irritation

H373:Causes damage to organs through prolonged or repeated exposure

H317:May cause an allergic skin reaction

H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled

H360:May damage fertility or the unborn child

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P284:[In case of inadequate ventilation] Wear respiratory protection.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P203:Obtain, read and follow all safety instructions before use.

P318:if exposed or concerned, get medical advice.

P319:Get medical help if you feel unwell.

P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.

WGK Germany 3

Related Documents

 SDS

 Specification Sheet

Alternative Products

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  3. G418 disulfate - 98%, used for , CAS No. 108321-42-2, by Aladdin Scientific
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Citations of This Product

How to Cite Aladdin Scientific Products?
1. Han Sijia, Jin Xueying, Hu Tianyu, Chi Feng.  (2023)  ARHGAP25 suppresses the development of breast cancer by an ARHGAP25/Wnt/ASCL2 feedback loop.  CARCINOGENESIS,      [PMID:37326327] [10.1093/carcin/bgad042]
2. Sijia Han, Xueying Jin, Tianyu Hu, Feng Chi.  (2023)  LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/β‑catenin pathway.  ONCOLOGY REPORTS,  49  (3): (1-14).  [PMID:36799186] [10.3892/or.2023.8497]
3. Jing Zhou, Tongyu Wu, Chun Li, Zhuozhou Hu, Liang Han, Xiangxiang Li, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen.  (2023)  Alfuzosin ameliorates diabetes by boosting PGK1 activity in diabetic mice.  LIFE SCIENCES,  317  (121491).  [PMID:36758669] [10.1016/j.lfs.2023.121491]
4. Zhuozhou Hu, Jing Zhou, Liang Han, Xiangxiang Li, Chun Li, Tongyu Wu, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen.  (2022)  Acyclovir alleviates insulin resistance via activating PKM1 in diabetic mice.  LIFE SCIENCES,  304  (120725).  [PMID:35751919] [10.1016/j.lfs.2022.120725]
5. Wu Liang, Wen Yongdi, Chen Wenying, Yan Tongshuai, Tian Xiaofei, Zhou Shishui.  (2021)  Simultaneously deleting ADH2 and THI3 genes of Saccharomyces cerevisiae for reducing the yield of acetaldehyde and fusel alcohols.  FEMS MICROBIOLOGY LETTERS,  368  (15):   [PMID:34410369] [10.1093/femsle/fnab094]
6. Jie Zhu, Kun Yang, Aijie Liu, Xiaoxue Lu, Linsong Yang, Qinghuan Zhao.  (2020)  Highly secretory expression of recombinant cowpea chlorotic mottle virus capsid proteins in Pichia pastoris and in-vitro encapsulation of ruthenium nanoparticles for catalysis.  PROTEIN EXPRESSION AND PURIFICATION,  174  (105679).  [PMID:32534017] [10.1016/j.pep.2020.105679]
7. 王帅.  (2024)  SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice.  Cell Death & Differentiation,  12  (9): (1407).  [PMID:39402212] [https://doi.org/10.1038/s41418-024-01397-0]

References

1. Ao R et al..  (2018)  Silencing of COL1A2, COL6A3, and THBS2 inhibits gastric cancer cell proliferation, migration, and invasion while promoting apoptosis through the PI3k-Akt signaling pathway..  J Cell Biochem,  119  (6): (4420-4434).  [PMID:29143985]
2. Gowthaman U et al..  (2021)  The Hda1 histone deacetylase limits divergent non-coding transcription and restricts transcription initiation frequency..  EMBO J,  40  (23): (e108903).  [PMID:34661296]
3. Han Sijia, Jin Xueying, Hu Tianyu, Chi Feng.  (2023)  ARHGAP25 suppresses the development of breast cancer by an ARHGAP25/Wnt/ASCL2 feedback loop.  CARCINOGENESIS,      [PMID:37326327] [10.1093/carcin/bgad042]
4. Sijia Han, Xueying Jin, Tianyu Hu, Feng Chi.  (2023)  LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/β‑catenin pathway.  ONCOLOGY REPORTS,  49  (3): (1-14).  [PMID:36799186] [10.3892/or.2023.8497]
5. Jing Zhou, Tongyu Wu, Chun Li, Zhuozhou Hu, Liang Han, Xiangxiang Li, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen.  (2023)  Alfuzosin ameliorates diabetes by boosting PGK1 activity in diabetic mice.  LIFE SCIENCES,  317  (121491).  [PMID:36758669] [10.1016/j.lfs.2023.121491]
6. Zhuozhou Hu, Jing Zhou, Liang Han, Xiangxiang Li, Chun Li, Tongyu Wu, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen.  (2022)  Acyclovir alleviates insulin resistance via activating PKM1 in diabetic mice.  LIFE SCIENCES,  304  (120725).  [PMID:35751919] [10.1016/j.lfs.2022.120725]
7. Wu Liang, Wen Yongdi, Chen Wenying, Yan Tongshuai, Tian Xiaofei, Zhou Shishui.  (2021)  Simultaneously deleting ADH2 and THI3 genes of Saccharomyces cerevisiae for reducing the yield of acetaldehyde and fusel alcohols.  FEMS MICROBIOLOGY LETTERS,  368  (15):   [PMID:34410369] [10.1093/femsle/fnab094]
8. Jie Zhu, Kun Yang, Aijie Liu, Xiaoxue Lu, Linsong Yang, Qinghuan Zhao.  (2020)  Highly secretory expression of recombinant cowpea chlorotic mottle virus capsid proteins in Pichia pastoris and in-vitro encapsulation of ruthenium nanoparticles for catalysis.  PROTEIN EXPRESSION AND PURIFICATION,  174  (105679).  [PMID:32534017] [10.1016/j.pep.2020.105679]
9. 王帅.  (2024)  SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice.  Cell Death & Differentiation,  12  (9): (1407).  [PMID:39402212] [https://doi.org/10.1038/s41418-024-01397-0]

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