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G 418 disulfate salt - powder, BioReagent, suitable for cell culture, high purity , CAS No.108321-42-2

  • BioReagent
  • for cell culture
  • powder
Item Number
G431375
Grouped product items
SKUSizeAvailabilityPrice Qty
G431375-1g
1g
In stock
$102.90
G431375-5g
5g
In stock
$408.90
G431375-25g
25g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,399.90
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Bulk Order  SDS  DATASHEET

Basic Description

Synonyms108321-42-2|G418 Disulfate|Geneticin (G418 Sulfate)|G 418 disulfate salt|(2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol
Specifications & Puritypowder, BioReagent, suitable for cell culture
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
GradeBioReagent, for cell culture
Product Description

Chemical structure: aminoglycoside G-418 is an aminoglycoside antibiotic, which is produced by Micromonospora rhodorangea NRRL 5326 strain. It has a broad range of antibacterial activity both in vivo and in vitro . It also shows activity against protozoa, cecal amoebiasis, and helminthes. It is commonly known as geneticin selective antibiotic.


Application

G418 disulfate is an aminoglycoside that is toxic to bacteria, yeast, protozoans and helminths. It prevents protein synthesis by blocking the elongation step in prokaryotic and eukaryotic ribosomes. It is used as a selection agent for G418 resistant bacteria or fungi after transformation.


Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Names and Identifiers

IUPAC Name (2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
INCHI InChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)/t6?,7-,8+,9+,10+,11-,12-,13-,14+,15+,16-,17-,18+,19-,20+;;/m0../s1
InChi Key UHEPSJJJMTWUCP-NKCAIAFTSA-N
Canonical SMILES CC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
Isomeric SMILES CC([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@H]3[C@H]([C@@H]([C@](CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
WGK Germany 3
PubChem CID 16218858
Molecular Weight 692.71

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

10 results found

Lot NumberCertificate TypeDateItem
A2408519Certificate of AnalysisDec 28, 2023 G431375
A2408521Certificate of AnalysisDec 28, 2023 G431375
A2408522Certificate of AnalysisDec 28, 2023 G431375
A2408524Certificate of AnalysisDec 28, 2023 G431375
F2320279Certificate of AnalysisMay 30, 2023 G431375
F2320282Certificate of AnalysisMay 30, 2023 G431375
F2320284Certificate of AnalysisMay 30, 2023 G431375
F2320286Certificate of AnalysisMay 30, 2023 G431375
F2320289Certificate of AnalysisMay 30, 2023 G431375
L2305152Certificate of AnalysisMay 30, 2023 G431375

Chemical and Physical Properties

SolubilityH2O: 100mg/mL (As a stock solution. Stock solutions should be stored at Store at 2-8°C. Stable at 37°C for 8 days.)
SensitivityMoisture,Heat sensitive
Specific Rotation[α]111 ° (C=0.3, H2O)
Melt Point(°C)138-144°C

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Danger
Hazard Statements

H335:May cause respiratory irritation

H373:Causes damage to organs through prolonged or repeated exposure

H317:May cause an allergic skin reaction

H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled

H360:May damage fertility or the unborn child

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P284:[In case of inadequate ventilation] Wear respiratory protection.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P203:Obtain, read and follow all safety instructions before use.

P318:if exposed or concerned, get medical advice.

P319:Get medical help if you feel unwell.

P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.

WGK Germany 3

Related Documents

 SDS

 Specification Sheet

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