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G 418 disulfate salt - powder, BioReagent, suitable for cell culture, high purity , CAS No.108321-42-2

5 Citations

BioReagent

for cell culture

powder

CAS#: 108321-42-2
Formula: C₂₀H₄₀N₄O₁₀·2H₂SO₄
Molecular Weight: 692.71
PubChem CID: 16218858

Item Number

G431375

Grouped product items
SKU	Size	Availability	Price
G431375-1g	1g	In stock	$102.90
G431375-5g	5g	In stock	$408.90
G431375-25g	25g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,399.90

Basic Description

Synonyms	AC-32603 \| G 418 disulfate salt \| (2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid \| C20H40N4O10.2H2SO4 \| G
Specifications & Purity	BioReagent, for cell culture, powder
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice
Grade	BioReagent, for cell culture
Product Description	Chemical structure: aminoglycoside G-418 is an aminoglycoside antibiotic, which is produced by Micromonospora rhodorangea NRRL 5326 strain. It has a broad range of antibacterial activity both in vivo and in vitro . It also shows activity against protozoa, cecal amoebiasis, and helminthes. It is commonly known as geneticin selective antibiotic. Application G418 disulfate is an aminoglycoside that is toxic to bacteria, yeast, protozoans and helminths. It prevents protein synthesis by blocking the elongation step in prokaryotic and eukaryotic ribosomes. It is used as a selection agent for G418 resistant bacteria or fungi after transformation. Other Notes Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Names and Identifiers

IUPAC Name	(2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
INCHI	InChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;21-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2(H2,1,2,3,4)/t6?,7-,8+,9+,10+,11-,12-,13-,14+,15+,16-,17-,18+,19-,20+;;/m0../s1
InChi Key	UHEPSJJJMTWUCP-NKCAIAFTSA-N
Canonical SMILES	CC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
Isomeric SMILES	CC([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@H]3[C@H]([C@@H]([C@](CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
WGK Germany	3
PubChem CID	16218858
Molecular Weight	692.71

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number	Certificate Type	Date	Item
A2408502	Certificate of Analysis	Dec 28, 2023	G431375
A2408519	Certificate of Analysis	Dec 28, 2023	G431375
A2408521	Certificate of Analysis	Dec 28, 2023	G431375
A2408522	Certificate of Analysis	Dec 28, 2023	G431375
A2408524	Certificate of Analysis	Dec 28, 2023	G431375
K2411029	Certificate of Analysis	Dec 28, 2023	G431375
F2320279	Certificate of Analysis	May 30, 2023	G431375
F2320282	Certificate of Analysis	May 30, 2023	G431375
F2320284	Certificate of Analysis	May 30, 2023	G431375
F2320286	Certificate of Analysis	May 30, 2023	G431375
F2320289	Certificate of Analysis	May 30, 2023	G431375
L2305152	Certificate of Analysis	May 30, 2023	G431375

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Chemical and Physical Properties

Solubility	H2O: 100mg/mL (As a stock solution. Stock solutions should be stored at Store at 2-8°C. Stable at 37°C for 8 days.)
Sensitivity	Moisture,Heat sensitive
Specific Rotation[α]	111 ° (C=0.3, H2O)
Melt Point(°C)	138-144°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H335:May cause respiratory irritation H373:Causes damage to organs through prolonged or repeated exposure H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H360:May damage fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.
WGK Germany	3

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Citations of This Product

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3. Jing Zhou, Tongyu Wu, Chun Li, Zhuozhou Hu, Liang Han, Xiangxiang Li, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen. (2023) Alfuzosin ameliorates diabetes by boosting PGK1 activity in diabetic mice. LIFE SCIENCES, 317 (121491). [PMID:36758669] [10.1016/j.lfs.2023.121491]
4. Zhuozhou Hu, Jing Zhou, Liang Han, Xiangxiang Li, Chun Li, Tongyu Wu, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen. (2022) Acyclovir alleviates insulin resistance via activating PKM1 in diabetic mice. LIFE SCIENCES, 304 (120725). [PMID:35751919] [10.1016/j.lfs.2022.120725]
5. Jie Zhu, Kun Yang, Aijie Liu, Xiaoxue Lu, Linsong Yang, Qinghuan Zhao. (2020) Highly secretory expression of recombinant cowpea chlorotic mottle virus capsid proteins in Pichia pastoris and in-vitro encapsulation of ruthenium nanoparticles for catalysis. PROTEIN EXPRESSION AND PURIFICATION, 174 (105679). [PMID:32534017] [10.1016/j.pep.2020.105679]
6. 王帅. (2024) SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice. Cell Death & Differentiation, 12 (9): (1407). [PMID:39402212] [https://doi.org/10.1038/s41418-024-01397-0]

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