Grouped product items

SKU

Size

Availability

Price

Qty

G431377-250mg

250mg

Available within 8-12 weeks(?)

$17.90

G431377-1g

Available within 8-12 weeks(?)

$58.90

G431377-5g

Available within 8-12 weeks(?)

$189.90

Basic Description

Synonyms	AC-32603 \| G 418 disulfate salt \| (2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid \| C20H40N4O10.2H2SO4 \| G
Specifications & Purity	potency: ≥720 μg per mg (dried basis)
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Product Description	General Description Chemical structure: aminoglycoside

Names and Identifiers

IUPAC Name	(2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
INCHI	InChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;21-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2(H2,1,2,3,4)/t6?,7-,8+,9+,10+,11-,12-,13-,14+,15+,16-,17-,18+,19-,20+;;/m0../s1
InChi Key	UHEPSJJJMTWUCP-NKCAIAFTSA-N
Canonical SMILES	CC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
Isomeric SMILES	CC([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@H]3[C@H]([C@@H]([C@](CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
WGK Germany	3
PubChem CID	16218858
Molecular Weight	692.71

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	H2O: 50mg/mL
Specific Rotation[α]	111 ° (C=0.3, H2O)
Melt Point(°C)	138-144°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H335:May cause respiratory irritation H373:Causes damage to organs through prolonged or repeated exposure H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H360:May damage fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.
WGK Germany	3

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Han Sijia, Jin Xueying, Hu Tianyu, Chi Feng. (2023) ARHGAP25 suppresses the development of breast cancer by an ARHGAP25/Wnt/ASCL2 feedback loop. CARCINOGENESIS, [PMID:37326327] [10.1093/carcin/bgad042]
2. Sijia Han, Xueying Jin, Tianyu Hu, Feng Chi. (2023) LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/β‑catenin pathway. ONCOLOGY REPORTS, 49 (3): (1-14). [PMID:36799186] [10.3892/or.2023.8497]
3. Jing Zhou, Tongyu Wu, Chun Li, Zhuozhou Hu, Liang Han, Xiangxiang Li, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen. (2023) Alfuzosin ameliorates diabetes by boosting PGK1 activity in diabetic mice. LIFE SCIENCES, 317 (121491). [PMID:36758669] [10.1016/j.lfs.2023.121491]
4. Zhuozhou Hu, Jing Zhou, Liang Han, Xiangxiang Li, Chun Li, Tongyu Wu, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen. (2022) Acyclovir alleviates insulin resistance via activating PKM1 in diabetic mice. LIFE SCIENCES, 304 (120725). [PMID:35751919] [10.1016/j.lfs.2022.120725]
5. Jie Zhu, Kun Yang, Aijie Liu, Xiaoxue Lu, Linsong Yang, Qinghuan Zhao. (2020) Highly secretory expression of recombinant cowpea chlorotic mottle virus capsid proteins in Pichia pastoris and in-vitro encapsulation of ruthenium nanoparticles for catalysis. PROTEIN EXPRESSION AND PURIFICATION, 174 (105679). [PMID:32534017] [10.1016/j.pep.2020.105679]
6. 王帅. (2024) SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice. Cell Death & Differentiation, 12 (9): (1407). [PMID:39402212] [https://doi.org/10.1038/s41418-024-01397-0]

References

1. Holger Stephan,Claire Concannon,Elisabeth Kremmer,Michael P Carty,Heinz-Peter Nasheuer. (2009-08-13) Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosis.. Nucleic acids research, 37 ((18)): (6028-6041). [PMID:19671522]
2. Qifan Zheng,Lei Han,Yucui Dong,Jing Tian,Wei Huang,Zhaoyu Liu,Xiuzhi Jia,Tao Jiang,Jianning Zhang,Xia Li,Chunsheng Kang,Huan Ren. (2014-05-28) JAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2/STAT3 axis and associated focal adhesion in EGFRvIII-expressing glioblastoma.. Neuro-oncology, 16 ((9)): (1229-1243). [PMID:24861878]
3. Saskia Willenbrock,Siegfried Wagner,Nicola Reimann-Berg,Mohammed Moulay,Marion Hewicker-Trautwein,Ingo Nolte,Hugo Murua Escobar. (2014-06-11) Generation and characterisation of a canine EGFP-HMGA2 prostate cancer in vitro model.. PloS one, 9 ((6)): (e98788-e98788). [PMID:24914948]
4. Arianna Crespi,Alessandra Bertoni,Ilaria Ferrari,Valeria Padovano,Pamela Della Mina,Emilio Berti,Antonello Villa,Grazia Pietrini. (2014-08-02) POF1B localizes to desmosomes and regulates cell adhesion in human intestinal and keratinocyte cell lines.. The Journal of investigative dermatology, 135 ((1)): (192-201). [PMID:25084053]
5. Yukinobu Kodama,Yumi Shiokawa,Tadahiro Nakamura,Tomoaki Kurosaki,Keisei Aki,Hiroo Nakagawa,Takahiro Muro,Takashi Kitahara,Norihide Higuchi,Hitoshi Sasaki. (2014-08-05) Novel siRNA delivery system using a ternary polymer complex with strong silencing effect and no cytotoxicity.. Biological & pharmaceutical bulletin, 37 ((8)): (1274-1281). [PMID:25087949]
6. Glenda Eger,Natalia Papadopoulos,Johan Lennartsson,Carl-Henrik Heldin. (2014-10-01) NR4A1 promotes PDGF-BB-induced cell colony formation in soft agar.. PloS one, 9 ((9)): (e109047-e109047). [PMID:25269081]
7. Laura Dato,Nadia Maria Berterame,Maria Antonietta Ricci,Paola Paganoni,Luigi Palmieri,Danilo Porro,Paola Branduardi. (2014-11-02) Changes in SAM2 expression affect lactic acid tolerance and lactic acid production in Saccharomyces cerevisiae.. Microbial cell factories, 13 (147-147). [PMID:25359316]
8. Gaelle del Castillo,Esther Sánchez-Blanco,Ester Martín-Villar,Ana C Valbuena-Diez,Carmen Langa,Eduardo Pérez-Gómez,Jaime Renart,Carmelo Bernabéu,Miguel Quintanilla. (2014-12-17) Soluble endoglin antagonizes Met signaling in spindle carcinoma cells.. Carcinogenesis, 36 ((2)): (212-222). [PMID:25503931]
9. Hao Zhang,Chunyang Xu,Rong Yang,Huanhuan Chen,Xiangqing Kong,Linmei Qian,Yanhui Sheng,Wei Sun. (2015-01-13) Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.. Experimental cell research, 331 ((2)): (369-376). [PMID:25576386]
10. Song-Fa Zhang,Xin-Yu Wang,Zhi-Qin Fu,Qiao-Hua Peng,Jian-Yang Zhang,Feng Ye,Yun-Feng Fu,Cai-Yun Zhou,Wei-Guo Lu,Xiao-Dong Cheng,Xing Xie. (2015-01-22) TXNDC17 promotes paclitaxel resistance via inducing autophagy in ovarian cancer.. Autophagy, 11 ((2)): (225-238). [PMID:25607466]
11. Wei Nie,Ming-Tzo Wei,H Daniel Ou-Yang,Sabrina S Jedlicka,Dimitrios Vavylonis. (2015-02-03) Formation of contractile networks and fibers in the medial cell cortex through myosin-II turnover, contraction, and stress-stabilization.. Cytoskeleton (Hoboken, N.J.), 72 ((1)): (29-46). [PMID:25641802]
12. Frida C Mohlin,Sara C Nilsson,Tanja Kersnik Levart,Ema Golubovic,Krisztina Rusai,Thomas Müller-Sacherer,Klaus Arbeiter,Éva Pállinger,Nóra Szarvas,Dorottya Csuka,Ágnes Szilágyi,Bruno O Villoutreix,Zoltán Prohászka,Anna M Blom. (2015-03-04) Functional characterization of two novel non-synonymous alterations in CD46 and a Q950H change in factor H found in atypical hemolytic uremic syndrome patients.. Molecular immunology, 65 ((2)): (367-376). [PMID:25733390]
13. Tomoya Narawa,Toshiaki Yano,Tomoo Itoh. (2015-04-04) Stereoselective recognition of amethopterin enantiomers by the rat proton-coupled folate transporter.. Biological & pharmaceutical bulletin, 38 ((4)): (545-551). [PMID:25832635]
14. Yun Hong,Lin Zhou,Haiyang Xie,Weilin Wang,Shusen Zheng. (2015-04-23) Differences in antiproliferative effect of STAT3 inhibition in HCC cells with versus without HBV expression.. Biochemical and biophysical research communications, 461 ((3)): (513-518). [PMID:25899746]
15. Patrick S Tawadros,Kinga A Powers,Menachem Ailenberg,Simone E Birch,John C Marshall,Katalin Szaszi,Andras Kapus,Ori D Rotstein. (2015-05-07) Oxidative Stress Increases Surface Toll-Like Receptor 4 Expression in Murine Macrophages Via Ceramide Generation.. Shock (Augusta, Ga.), 44 ((2)): (157-165). [PMID:25944793]
16. Ying Wang,Jianxun Mi,Ka Lu,Yanxin Lu,KeWei Wang. (2015-06-13) Comparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and Lidocaine.. PloS one, 10 ((6)): (e0128653-e0128653). [PMID:26068619]
17. Elsa A Marquez,Kevin P Kane. (2015-07-07) Identities of P2 and P3 Residues of H-2Kb-Bound Peptides Determine Mouse Ly49C Recognition.. PloS one, 10 ((7)): (e0131308-e0131308). [PMID:26147851]
18. Hua Zhang,Lei Song,Haolong Cong,Po Tien. (2015-07-24) Nuclear Protein Sam68 Interacts with the Enterovirus 71 Internal Ribosome Entry Site and Positively Regulates Viral Protein Translation.. Journal of virology, 89 ((19)): (10031-10043). [PMID:26202240]
19. Terezie Imrichova,Sona Hubackova,Alena Kucerova,Jan Kosla,Jiri Bartek,Zdenek Hodny,Pavla Vasicova. (2019-09-08) Dynamic PML protein nucleolar associations with persistent DNA damage lesions in response to nucleolar stress and senescence-inducing stimuli.. Aging, 11 ((17)): (7206-7235). [PMID:31493766]
20. Shijia Yu,Mingjun Yu,Zhongqi Bu,Pingping He,Juan Feng. (2020-08-08) FKBP5 Exacerbates Impairments in Cerebral Ischemic Stroke by Inducing Autophagy via the AKT/FOXO3 Pathway.. Frontiers in cellular neuroscience, 14 (193-193). [PMID:32760250]
21. Yoshie Tange,Atsushi Kurabayashi,Bunshiro Goto,Kwang-Lae Hoe,Dong-Uk Kim,Han-Oh Park,Jacqueline Hayles,Yuji Chikashige,Chihiro Tsutumi,Yasushi Hiraoka,Fumiaki Yamao,Paul Nurse,Osami Niwa. (2012-06-28) The CCR4-NOT complex is implicated in the viability of aneuploid yeasts.. PLoS genetics, 8 ((6)): (e1002776-e1002776). [PMID:22737087]
22. Luis M Molinos-Albert,Jorge Carrillo,Marta Curriu,Maria L Rodriguez de la Concepción,Silvia Marfil,Elisabet García,Bonaventura Clotet,Julià Blanco. (2014-06-10) Anti-MPER antibodies with heterogeneous neutralization capacity are detectable in most untreated HIV-1 infected individuals.. Retrovirology, 11 (44-44). [PMID:24909946]
23. Osamu Nakabayashi,Hirotaka Takahashi,Kenta Moriwaki,Sachiko Komazawa-Sakon,Fumiaki Ohtake,Shin Murai,Yuichi Tsuchiya,Yuki Koyahara,Yasushi Saeki,Yukiko Yoshida,Soh Yamazaki,Fuminori Tokunaga,Tatsuya Sawasaki,Hiroyasu Nakano. (2021-01-21) MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL.. Communications biology, 4 ((1)): (80-80). [PMID:33469115]
24. Han Sijia, Jin Xueying, Hu Tianyu, Chi Feng. (2023) ARHGAP25 suppresses the development of breast cancer by an ARHGAP25/Wnt/ASCL2 feedback loop. CARCINOGENESIS, [PMID:37326327] [10.1093/carcin/bgad042]
25. Sijia Han, Xueying Jin, Tianyu Hu, Feng Chi. (2023) LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/β‑catenin pathway. ONCOLOGY REPORTS, 49 (3): (1-14). [PMID:36799186] [10.3892/or.2023.8497]
26. Jing Zhou, Tongyu Wu, Chun Li, Zhuozhou Hu, Liang Han, Xiangxiang Li, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen. (2023) Alfuzosin ameliorates diabetes by boosting PGK1 activity in diabetic mice. LIFE SCIENCES, 317 (121491). [PMID:36758669] [10.1016/j.lfs.2023.121491]
27. Zhuozhou Hu, Jing Zhou, Liang Han, Xiangxiang Li, Chun Li, Tongyu Wu, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen. (2022) Acyclovir alleviates insulin resistance via activating PKM1 in diabetic mice. LIFE SCIENCES, 304 (120725). [PMID:35751919] [10.1016/j.lfs.2022.120725]
28. Jie Zhu, Kun Yang, Aijie Liu, Xiaoxue Lu, Linsong Yang, Qinghuan Zhao. (2020) Highly secretory expression of recombinant cowpea chlorotic mottle virus capsid proteins in Pichia pastoris and in-vitro encapsulation of ruthenium nanoparticles for catalysis. PROTEIN EXPRESSION AND PURIFICATION, 174 (105679). [PMID:32534017] [10.1016/j.pep.2020.105679]
29. 王帅. (2024) SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice. Cell Death & Differentiation, 12 (9): (1407). [PMID:39402212] [https://doi.org/10.1038/s41418-024-01397-0]

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G 418 disulfate salt - potency: ≥720 μg per mg (dried basis), high purity , CAS No.108321-42-2

Basic Description

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price
G431377-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$17.90
G431377-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$58.90
G431377-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$189.90