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G 418 disulfate salt solution - 50 mg/mL in H2O, 0.1 μm filtered, BioReagent, suitable for cell culture, high purity , CAS No.108321-42-2

5 Citations
Item Number
G431374
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SKUSizeAvailabilityPrice Qty
G431374-10ml
10ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$263.90
G431374-50ml
50ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,102.90
G431374-100ml
100ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,529.90
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Basic Description

SynonymsAC-32603 | G 418 disulfate salt | (2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid | C20H40N4O10.2H2SO4 | G
Specifications & PurityBioReagent, for cell culture, 0.1 μm filtered, 50 mg/mL in H2O
Storage TempStore at 2-8°C
Shipped InWet ice
GradeBioReagent, for cell culture
Product Description

Chemical structure: aminoglycoside


Application

G418 disulfate is an aminoglycoside antibiotic similar in structure to gentamicin used for selection and maintenance of prokaryotic and eukaryotic cells. Optimal concentrations for selection and maintenance vary by cell lines. Bacteria and algae require 5 μg/mL or less while animal cells may require 300-500 μg/mL.

Names and Identifiers

IUPAC Name (2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
INCHI InChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)/t6?,7-,8+,9+,10+,11-,12-,13-,14+,15+,16-,17-,18+,19-,20+;;/m0../s1
InChi Key UHEPSJJJMTWUCP-NKCAIAFTSA-N
Canonical SMILES CC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
Isomeric SMILES CC([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@H]3[C@H]([C@@H]([C@](CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
WGK Germany 3
PubChem CID 16218858
Molecular Weight 692.71

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilityH2O: 50mg/mL, clear
Specific Rotation[α]111 ° (C=0.3, H2O)
Melt Point(°C)138-144°C

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Danger
Hazard Statements

H335:May cause respiratory irritation

H373:Causes damage to organs through prolonged or repeated exposure

H317:May cause an allergic skin reaction

H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled

H360:May damage fertility or the unborn child

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P284:[In case of inadequate ventilation] Wear respiratory protection.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P203:Obtain, read and follow all safety instructions before use.

P318:if exposed or concerned, get medical advice.

P319:Get medical help if you feel unwell.

P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.

WGK Germany 3

Related Documents

 SDS

 Specification Sheet

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Han Sijia, Jin Xueying, Hu Tianyu, Chi Feng.  (2023)  ARHGAP25 suppresses the development of breast cancer by an ARHGAP25/Wnt/ASCL2 feedback loop.  CARCINOGENESIS,      [PMID:37326327] [10.1093/carcin/bgad042]
2. Sijia Han, Xueying Jin, Tianyu Hu, Feng Chi.  (2023)  LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/β‑catenin pathway.  ONCOLOGY REPORTS,  49  (3): (1-14).  [PMID:36799186] [10.3892/or.2023.8497]
3. Jing Zhou, Tongyu Wu, Chun Li, Zhuozhou Hu, Liang Han, Xiangxiang Li, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen.  (2023)  Alfuzosin ameliorates diabetes by boosting PGK1 activity in diabetic mice.  LIFE SCIENCES,  317  (121491).  [PMID:36758669] [10.1016/j.lfs.2023.121491]
4. Zhuozhou Hu, Jing Zhou, Liang Han, Xiangxiang Li, Chun Li, Tongyu Wu, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen.  (2022)  Acyclovir alleviates insulin resistance via activating PKM1 in diabetic mice.  LIFE SCIENCES,  304  (120725).  [PMID:35751919] [10.1016/j.lfs.2022.120725]
5. Jie Zhu, Kun Yang, Aijie Liu, Xiaoxue Lu, Linsong Yang, Qinghuan Zhao.  (2020)  Highly secretory expression of recombinant cowpea chlorotic mottle virus capsid proteins in Pichia pastoris and in-vitro encapsulation of ruthenium nanoparticles for catalysis.  PROTEIN EXPRESSION AND PURIFICATION,  174  (105679).  [PMID:32534017] [10.1016/j.pep.2020.105679]
6. 王帅.  (2024)  SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice.  Cell Death & Differentiation,  12  (9): (1407).  [PMID:39402212] [https://doi.org/10.1038/s41418-024-01397-0]

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