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G418 disulfate - 98%, high purity , CAS No.108321-42-2

6 Citations
  • ≥98%
Item Number
G274348
Grouped product items
SKUSizeAvailabilityPrice Qty
G274348-1g
1g
In stock
$60.90
G274348-5g
5g
In stock
$181.90
G274348-25g
25g
In stock
$753.90
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Basic Description

SynonymsAC-32603 | G 418 disulfate salt | (2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid | C20H40N4O10.2H2SO4 | G
Specifications & Purity≥98%
Biochemical and Physiological MechanismsG-418 inhibits protein synthesis at the early stages of elongation, post-initiation, at the initiation stage of translation as well as just before the initiation stage of translation.
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
Product Description

Selection agent for both prokaryotic and eukaryotic transfected cells. An aminoglycoside similar to gentamycin, G418 is toxic to bacterial, yeast, higher plant and mammalian cells, protozoans, and helminths.


application：

G418 disulfate is used for selection and maintenance of prokaryotic and eukaryotic cells transfected with a iNOS promoter construct and neomycin resistance gene. Optimal concentrations for selection and maintenance vary by cell lines.

Names and Identifiers

IUPAC Name (2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
INCHI InChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)/t6?,7-,8+,9+,10+,11-,12-,13-,14+,15+,16-,17-,18+,19-,20+;;/m0../s1
InChi Key UHEPSJJJMTWUCP-NKCAIAFTSA-N
Canonical SMILES CC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
Isomeric SMILES CC([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@H]3[C@H]([C@@H]([C@](CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
WGK Germany 3
PubChem CID 16218858
Molecular Weight 692.71

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

25 results found

Lot NumberCertificate TypeDateItem
F2418232Certificate of AnalysisJun 11, 2024 G274348
F2418231Certificate of AnalysisJun 11, 2024 G274348
F2418230Certificate of AnalysisJun 11, 2024 G274348
D2402252Certificate of AnalysisMar 21, 2024 G274348
D2402250Certificate of AnalysisMar 21, 2024 G274348
L2301229Certificate of AnalysisNov 21, 2023 G274348
L2301228Certificate of AnalysisNov 21, 2023 G274348
H2331536Certificate of AnalysisAug 19, 2023 G274348
H2331534Certificate of AnalysisAug 19, 2023 G274348
H2331529Certificate of AnalysisAug 19, 2023 G274348
G2305809Certificate of AnalysisJun 09, 2023 G274348
G2305753Certificate of AnalysisJun 09, 2023 G274348
G23051225Certificate of AnalysisJun 09, 2023 G274348
G23051217Certificate of AnalysisJun 09, 2023 G274348
A2329647Certificate of AnalysisNov 30, 2022 G274348
A2329648Certificate of AnalysisNov 30, 2022 G274348
A2329652Certificate of AnalysisNov 30, 2022 G274348
A2329670Certificate of AnalysisNov 30, 2022 G274348
A2329691Certificate of AnalysisNov 30, 2022 G274348
G2208074Certificate of AnalysisJun 10, 2022 G274348
G2208073Certificate of AnalysisJun 10, 2022 G274348
G2208072Certificate of AnalysisJun 10, 2022 G274348
B2210365Certificate of AnalysisJan 03, 2022 G274348
B2210378Certificate of AnalysisJan 03, 2022 G274348
B2210426Certificate of AnalysisJan 03, 2022 G274348

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Chemical and Physical Properties

SolubilityDifficult to mix.
SensitivityMoisture & heat sensitive
Specific Rotation[α]111 ° (C=0.3, H2O)
Melt Point(°C)138-144°C

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Danger
Hazard Statements

H335:May cause respiratory irritation

H373:Causes damage to organs through prolonged or repeated exposure

H317:May cause an allergic skin reaction

H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled

H360:May damage fertility or the unborn child

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P284:[In case of inadequate ventilation] Wear respiratory protection.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P203:Obtain, read and follow all safety instructions before use.

P318:if exposed or concerned, get medical advice.

P319:Get medical help if you feel unwell.

P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.

WGK Germany 3

Related Documents

 SDS

 Specification Sheet

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Citations of This Product

How to Cite Aladdin Scientific Products?
1. Han Sijia, Jin Xueying, Hu Tianyu, Chi Feng.  (2023)  ARHGAP25 suppresses the development of breast cancer by an ARHGAP25/Wnt/ASCL2 feedback loop.  CARCINOGENESIS,      [PMID:37326327] [10.1093/carcin/bgad042]
2. Sijia Han, Xueying Jin, Tianyu Hu, Feng Chi.  (2023)  LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/β‑catenin pathway.  ONCOLOGY REPORTS,  49  (3): (1-14).  [PMID:36799186] [10.3892/or.2023.8497]
3. Jing Zhou, Tongyu Wu, Chun Li, Zhuozhou Hu, Liang Han, Xiangxiang Li, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen.  (2023)  Alfuzosin ameliorates diabetes by boosting PGK1 activity in diabetic mice.  LIFE SCIENCES,  317  (121491).  [PMID:36758669] [10.1016/j.lfs.2023.121491]
4. Zhuozhou Hu, Jing Zhou, Liang Han, Xiangxiang Li, Chun Li, Tongyu Wu, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen.  (2022)  Acyclovir alleviates insulin resistance via activating PKM1 in diabetic mice.  LIFE SCIENCES,  304  (120725).  [PMID:35751919] [10.1016/j.lfs.2022.120725]
5. Wu Liang, Wen Yongdi, Chen Wenying, Yan Tongshuai, Tian Xiaofei, Zhou Shishui.  (2021)  Simultaneously deleting ADH2 and THI3 genes of Saccharomyces cerevisiae for reducing the yield of acetaldehyde and fusel alcohols.  FEMS MICROBIOLOGY LETTERS,  368  (15):   [PMID:34410369] [10.1093/femsle/fnab094]
6. Jie Zhu, Kun Yang, Aijie Liu, Xiaoxue Lu, Linsong Yang, Qinghuan Zhao.  (2020)  Highly secretory expression of recombinant cowpea chlorotic mottle virus capsid proteins in Pichia pastoris and in-vitro encapsulation of ruthenium nanoparticles for catalysis.  PROTEIN EXPRESSION AND PURIFICATION,  174  (105679).  [PMID:32534017] [10.1016/j.pep.2020.105679]
7. 王帅.  (2024)  SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice.  Cell Death & Differentiation,  12  (9): (1407).  [PMID:39402212] [https://doi.org/10.1038/s41418-024-01397-0]

References

1. Han Sijia, Jin Xueying, Hu Tianyu, Chi Feng.  (2023)  ARHGAP25 suppresses the development of breast cancer by an ARHGAP25/Wnt/ASCL2 feedback loop.  CARCINOGENESIS,      [PMID:37326327] [10.1093/carcin/bgad042]
2. Sijia Han, Xueying Jin, Tianyu Hu, Feng Chi.  (2023)  LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/β‑catenin pathway.  ONCOLOGY REPORTS,  49  (3): (1-14).  [PMID:36799186] [10.3892/or.2023.8497]
3. Jing Zhou, Tongyu Wu, Chun Li, Zhuozhou Hu, Liang Han, Xiangxiang Li, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen.  (2023)  Alfuzosin ameliorates diabetes by boosting PGK1 activity in diabetic mice.  LIFE SCIENCES,  317  (121491).  [PMID:36758669] [10.1016/j.lfs.2023.121491]
4. Zhuozhou Hu, Jing Zhou, Liang Han, Xiangxiang Li, Chun Li, Tongyu Wu, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen.  (2022)  Acyclovir alleviates insulin resistance via activating PKM1 in diabetic mice.  LIFE SCIENCES,  304  (120725).  [PMID:35751919] [10.1016/j.lfs.2022.120725]
5. Wu Liang, Wen Yongdi, Chen Wenying, Yan Tongshuai, Tian Xiaofei, Zhou Shishui.  (2021)  Simultaneously deleting ADH2 and THI3 genes of Saccharomyces cerevisiae for reducing the yield of acetaldehyde and fusel alcohols.  FEMS MICROBIOLOGY LETTERS,  368  (15):   [PMID:34410369] [10.1093/femsle/fnab094]
6. Jie Zhu, Kun Yang, Aijie Liu, Xiaoxue Lu, Linsong Yang, Qinghuan Zhao.  (2020)  Highly secretory expression of recombinant cowpea chlorotic mottle virus capsid proteins in Pichia pastoris and in-vitro encapsulation of ruthenium nanoparticles for catalysis.  PROTEIN EXPRESSION AND PURIFICATION,  174  (105679).  [PMID:32534017] [10.1016/j.pep.2020.105679]
7. 王帅.  (2024)  SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice.  Cell Death & Differentiation,  12  (9): (1407).  [PMID:39402212] [https://doi.org/10.1038/s41418-024-01397-0]

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