Basic Description

Synonyms	AC-32603 \| G 418 disulfate salt \| (2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid \| C20H40N4O10.2H2SO4 \| G
Specifications & Purity	25mg/ml, Sterilized
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Names and Identifiers

IUPAC Name	(2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
INCHI	InChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;21-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2(H2,1,2,3,4)/t6?,7-,8+,9+,10+,11-,12-,13-,14+,15+,16-,17-,18+,19-,20+;;/m0../s1
InChi Key	UHEPSJJJMTWUCP-NKCAIAFTSA-N
Canonical SMILES	CC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
Isomeric SMILES	CC([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@H]3[C@H]([C@@H]([C@](CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
WGK Germany	3
PubChem CID	16218858
Molecular Weight	692.71

Certificates

Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
J2416834	Certificate of Analysis	Oct 18, 2024	G301863
L2106991	Certificate of Analysis	Jan 10, 2022	G301863

Chemical and Physical Properties

Specific Rotation[α]	111 ° (C=0.3, H2O)
Melt Point(°C)	138-144°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H335:May cause respiratory irritation H373:Causes damage to organs through prolonged or repeated exposure H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H360:May damage fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.
WGK Germany	3

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Han Sijia, Jin Xueying, Hu Tianyu, Chi Feng. (2023) ARHGAP25 suppresses the development of breast cancer by an ARHGAP25/Wnt/ASCL2 feedback loop. CARCINOGENESIS, [PMID:37326327] [10.1093/carcin/bgad042]
2. Sijia Han, Xueying Jin, Tianyu Hu, Feng Chi. (2023) LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/β‑catenin pathway. ONCOLOGY REPORTS, 49 (3): (1-14). [PMID:36799186] [10.3892/or.2023.8497]
3. Jing Zhou, Tongyu Wu, Chun Li, Zhuozhou Hu, Liang Han, Xiangxiang Li, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen. (2023) Alfuzosin ameliorates diabetes by boosting PGK1 activity in diabetic mice. LIFE SCIENCES, 317 (121491). [PMID:36758669] [10.1016/j.lfs.2023.121491]
4. Zhuozhou Hu, Jing Zhou, Liang Han, Xiangxiang Li, Chun Li, Tongyu Wu, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen. (2022) Acyclovir alleviates insulin resistance via activating PKM1 in diabetic mice. LIFE SCIENCES, 304 (120725). [PMID:35751919] [10.1016/j.lfs.2022.120725]
5. Wu Liang, Wen Yongdi, Chen Wenying, Yan Tongshuai, Tian Xiaofei, Zhou Shishui. (2021) Simultaneously deleting ADH2 and THI3 genes of Saccharomyces cerevisiae for reducing the yield of acetaldehyde and fusel alcohols. FEMS MICROBIOLOGY LETTERS, 368 (15): [PMID:34410369] [10.1093/femsle/fnab094]
6. Jie Zhu, Kun Yang, Aijie Liu, Xiaoxue Lu, Linsong Yang, Qinghuan Zhao. (2020) Highly secretory expression of recombinant cowpea chlorotic mottle virus capsid proteins in Pichia pastoris and in-vitro encapsulation of ruthenium nanoparticles for catalysis. PROTEIN EXPRESSION AND PURIFICATION, 174 (105679). [PMID:32534017] [10.1016/j.pep.2020.105679]
7. 王帅. (2024) SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice. Cell Death & Differentiation, 12 (9): (1407). [PMID:39402212] [https://doi.org/10.1038/s41418-024-01397-0]

References

1. Han Sijia, Jin Xueying, Hu Tianyu, Chi Feng. (2023) ARHGAP25 suppresses the development of breast cancer by an ARHGAP25/Wnt/ASCL2 feedback loop. CARCINOGENESIS, [PMID:37326327] [10.1093/carcin/bgad042]
2. Sijia Han, Xueying Jin, Tianyu Hu, Feng Chi. (2023) LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/β‑catenin pathway. ONCOLOGY REPORTS, 49 (3): (1-14). [PMID:36799186] [10.3892/or.2023.8497]
3. Jing Zhou, Tongyu Wu, Chun Li, Zhuozhou Hu, Liang Han, Xiangxiang Li, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen. (2023) Alfuzosin ameliorates diabetes by boosting PGK1 activity in diabetic mice. LIFE SCIENCES, 317 (121491). [PMID:36758669] [10.1016/j.lfs.2023.121491]
4. Zhuozhou Hu, Jing Zhou, Liang Han, Xiangxiang Li, Chun Li, Tongyu Wu, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen. (2022) Acyclovir alleviates insulin resistance via activating PKM1 in diabetic mice. LIFE SCIENCES, 304 (120725). [PMID:35751919] [10.1016/j.lfs.2022.120725]
5. Wu Liang, Wen Yongdi, Chen Wenying, Yan Tongshuai, Tian Xiaofei, Zhou Shishui. (2021) Simultaneously deleting ADH2 and THI3 genes of Saccharomyces cerevisiae for reducing the yield of acetaldehyde and fusel alcohols. FEMS MICROBIOLOGY LETTERS, 368 (15): [PMID:34410369] [10.1093/femsle/fnab094]
6. Jie Zhu, Kun Yang, Aijie Liu, Xiaoxue Lu, Linsong Yang, Qinghuan Zhao. (2020) Highly secretory expression of recombinant cowpea chlorotic mottle virus capsid proteins in Pichia pastoris and in-vitro encapsulation of ruthenium nanoparticles for catalysis. PROTEIN EXPRESSION AND PURIFICATION, 174 (105679). [PMID:32534017] [10.1016/j.pep.2020.105679]
7. 王帅. (2024) SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice. Cell Death & Differentiation, 12 (9): (1407). [PMID:39402212] [https://doi.org/10.1038/s41418-024-01397-0]

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G418 Solution - 25mg/ml, Sterilized, high purity , CAS No.108321-42-2