Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	G6PDi-1 is an effective inhibitor of glucose-6-phosphate dehydrogenase (G6PD). G6PDi-1 depletes NADPH and decreases inflammatory cytokine production.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Information G6PDi-1 G6PDi-1 is an effective inhibitor of glucose-6-phosphate dehydrogenase (G6PD) . G6PDi-1 depletes NADPH and decreases inflammatory cytokine production. Targets G6PD ; NADPH In vitro G6PDi-1 effectively inhibits G6PD. Across a range of cultured cells, G6PDi-1 depletes NADPH most strongly in lymphocytes. In T cells but not macrophages, G6PDi-1 markedly decreases inflammatory cytokine production. In neutrophils, it suppresses respiratory burst. Cell Research(from reference) Cell lines：HepG2 cells, HCT116 cells, T cells Concentrations：25 μM, 50 μM, 75 μM, 100 μM Incubation Time：2 h, 4 h, 6 h

Associated Targets(Human)

G6PD Tchem Glucose-6-phosphate 1-dehydrogenase (778 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IUPAC Name	4-[(5-oxo-6,7,8,9-tetrahydrocyclohepta[d]pyrimidin-2-yl)amino]thiophene-2-carbonitrile
INCHI	InChI=1S/C14H12N4OS/c15-6-10-5-9(8-20-10)17-14-16-7-11-12(18-14)3-1-2-4-13(11)19/h5,7-8H,1-4H2,(H,16,17,18)
InChi Key	USWCHVCZOGGQQA-UHFFFAOYSA-N
Canonical SMILES	C1CCC(=O)C2=CN=C(N=C2C1)NC3=CSC(=C3)C#N
Isomeric SMILES	C1CCC(=O)C2=CN=C(N=C2C1)NC3=CSC(=C3)C#N
PubChem CID	145998284
Molecular Weight	284.34

Enter Lot Number to search for COA:

Solubility	Solubility (25°C) In vitro DMSO: 57 mg/mL (200.46 mM); Water: Insoluble; Ethanol: Insoluble;

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.