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Gabazine , CAS No.105538-73-6, Antagonist of GABA A receptor α1 subunit;Antagonist of GABA A receptor α2 subunit;Antagonist of GABA A receptor α3 subunit;Antagonist of GABA A receptor α4 subunit;Antagonist of GABA A receptor α5 subunit;Antagonist of GABA A receptor α6 subunit

Moligand™

CAS#: 105538-73-6
Formula: C₁₅H₁₇N₃O₃
Molecular Weight: 287.31
PubChem CID: 107896

Item Number

G338500

Grouped product items
SKU	Size	Availability	Price	Qty
G338500-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$321.90

a specific GABA receptor antagonist

View related series

GABAA receptor α1 subunit Antagonist GABAA receptor α2 subunit Antagonist GABAA receptor α3 subunit Antagonist GABAA receptor α4 subunit Antagonist GABAA receptor α5 subunit Antagonist GABAA receptor α6 subunit Antagonist

Basic Description

Synonyms	Gabazine\|105538-73-6\|Gabazine free base\|SR95531\|CHEBI:34968\|Tocris-1262\|C13796\|4-(6-imino-3-(4-methoxyphenyl)pyridazin-1(6H)-yl)butanoic acid\|J331.170H\|Prestwick0_000443\|Prestwick1_000443\|Prestwick2_000443\|1(6H)-Pyridazinebutanoic acid, 6-imino-3-(4-metho
Specifications & Purity	Moligand™
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of GABA A receptor α1 subunit;Antagonist of GABA A receptor α2 subunit;Antagonist of GABA A receptor α3 subunit;Antagonist of GABA A receptor α4 subunit;Antagonist of GABA A receptor α5 subunit;Antagonist of GABA A receptor α6 subunit
Product Description	Gabazine is a specific GABA receptor antagonist which does not affect GABA-transaminase or glutamate-decarboxylase activitites.

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRR3 Tbio Gamma-aminobutyric acid receptor subunit rho-3 0 Activities

Discover Target: GABRR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRG2 Tclin Gamma-aminobutyric acid receptor subunit gamma-2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA3 Tclin Gamma-aminobutyric acid receptor subunit alpha-3 0 Activities

Discover Target: GABRA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA4 Tclin Gamma-aminobutyric acid receptor subunit alpha-4 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA5 Tclin Gamma-aminobutyric acid receptor subunit alpha-5 0 Activities

Discover Target: GABRA5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA2 Tclin Gamma-aminobutyric acid receptor subunit alpha-2 0 Activities

Discover Target: GABRA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA6 Tclin Gamma-aminobutyric acid receptor subunit alpha-6 0 Activities

Discover Target: GABRA6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RUNX1 Tbio Runt-related transcription factor 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 0 Activities

Discover Target: HSD17B10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

Discover Target: ALOX15

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ARSA Tbio Arylsulfatase A 0 Activities

Discover Target: ARSA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IMPA1 Tclin Inositol monophosphatase 1 0 Activities

Discover Target: IMPA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid
INCHI	InChI=1S/C15H17N3O3/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20/h4-9,16H,2-3,10H2,1H3,(H,19,20)
InChi Key	ACVGNKYJVGNLIL-UHFFFAOYSA-N
Canonical SMILES	COC1=CC=C(C=C1)C2=NN(C(=N)C=C2)CCCC(=O)O
Isomeric SMILES	COC1=CC=C(C=C1)C2=NN(C(=N)C=C2)CCCC(=O)O
Alternate CAS	105538-73-6
PubChem CID	107896
MeSH Entry Terms	6-amino-5-methyl-3-(4-methoxyphenyl)-1-pyridaziniumbutyric acid, bromide;gabazine;SR 95531;SR-95531
Molecular Weight	287.31

Solubility

Soluble in DMSO and Methanol

Melt Point(°C)

244-248° C

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