THIP (Gaboxadol) is a selective extrasynaptic GABAA receptors (eGABARs) agonist (with blood-brain barrier permeability), shows an EC50 value of 13 µM for δ-GABAAR. THIP induces strong tense GABAA-mediated currents in layer 2/3 neurons, but shows on effect
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST, ANTAGONIST
Mechanism of action
GABA-A receptor; agonist GABA site agonist
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
1.Rudolph S et al.. (2020) Cerebellum-Specific Deletion of the GABAA Receptor d Subunit Leads to Sex-Specific Disruption of Behavior.. Cell Rep, 33 (5):(108338). [PMID:33147470]
2.Luo R et al.. (2013) Distinct roles of synaptic and extrasynaptic GABAAreceptors in striatal inhibition dynamics.. Front Neural Circuits, 7 (186). [PMID:24324406]
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