galidesivir , Replicase polyprotein 1ab inhibitor, CAS No.249503-25-1, Replicase polyprotein 1ab inhibitor

Item Number

G610487

Grouped product items
SKU	Size	Availability	Price	Qty
G610487-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$310.90
G610487-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,060.90

Basic Description

Synonyms	Galidesivir\|249503-25-1\|IMMUCILLIN A\|Immucillin-A\|BCX4430\|BCX-4430\|BCX 4430 Free Base\|(2S,3S,4R,5R)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol\|OLF97F86A7\|BCX4430 freebase\|ImmA cpd\|3,4-Pyrrolidinediol,2-(4-Amino-5h-Py
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Replicase polyprotein 1ab inhibitor

Names and Identifiers

IUPAC Name	(2S,3S,4R,5R)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol
INCHI	InChI=1S/C11H15N5O3/c12-11-8-6(14-3-15-11)4(1-13-8)7-10(19)9(18)5(2-17)16-7/h1,3,5,7,9-10,13,16-19H,2H2,(H2,12,14,15)/t5-,7+,9-,10+/m1/s1
InChi Key	AMFDITJFBUXZQN-KUBHLMPHSA-N
Canonical SMILES	C1=C(C2=C(N1)C(=NC=N2)N)C3C(C(C(N3)CO)O)O
Isomeric SMILES	C1=C(C2=C(N1)C(=NC=N2)N)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O
Alternate CAS	249503-25-1
PubChem CID	10445549
MeSH Entry Terms	2-(4-amino-5H-pyrrolo(3,2-d)pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol;BCX-4430;BCX4430;Galidesivir;ImmA cpd;immucillin A;immucillin-A
Molecular Weight	265.27

PubChem CID

CAS Registry No.

ChEMBL Ligand

BindingDB Ligand

DrugBank Ligand

RCSB PDB Ligand

References

1. Warren TK, Wells J, Panchal RG, Stuthman KS, Garza NL, Van Tongeren SA, Dong L, Retterer CJ, Eaton BP, Pegoraro G et al.. (2014) Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.. Nature, 508 (7496): (402-5). [PMID:24590073]
2. Bernatchez JA, Tran LT, Li J, Luan Y, Siqueira-Neto JL, Li R. (2020) Drugs for the Treatment of Zika Virus Infection.. J Med Chem, 63 (2): (470-489). [PMID:31549836]
3. Choy KT, Wong AY, Kaewpreedee P, Sia SF, Chen D, Hui KPY, Chu DKW, Chan MCW, Cheung PP, Huang X et al.. (2020) Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro.. Antiviral Res, 178 (3): (104786). [PMID:32251767]

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Basic Description