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Galiximab (anti-CD80) - Primary antibody, specific to CD80, >95%, high purity, Human IgG1, INHIBITOR of T-lymphocyte activation antigen CD80 inhibitor

  • Azide Free
  • Carrier Free
  • ExactAb™
  • Low Endotoxin
  • Recombinant
  • Validated
  • ≥95%(SDS-PAGE&SEC)
  • Lot by Lot
Features and benefits
  • Short Overview:

    Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

  • Species reactivity(Reacts with): Cynomolgus monkey,Human
  • Isotype: Human IgG1
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
Item Number
Ab177850
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab177850-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
Ab177850-1mg
1mg
In stock
$279.90
Ab177850-5mg
5mg
In stock
$909.90
Ab177850-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,429.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Accession#:P33681 CD80 Gene ID:941

Basic Description

Product NameGaliximab (anti-CD80) - Primary antibody, specific to CD80, >95%, high purity, Human IgG1
SynonymsActivation B7-1 antigen antibody; B lymphocyte activation antigen B7 antibody; B7 antibody; B7-1 antibody; B7-1 antigen antibody; B7.1 antibody; BB1 antibody; CD28 antigen ligand 1 antibody; CD28LG antibody; CD28LG1 antibody; CD80 antibody; CD80 antigen (
Specifications & PurityExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
SpecificityCD80
ConjugationUnconjugated
GradeAzide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action TypeINHIBITOR
Mechanism of actionINHIBITOR of T-lymphocyte activation antigen CD80 inhibitor
Product Description

Galiximab (anti-CD80) is a primatized immunoglobulin G1 (IgG1) lambda monoclonal antibody directed against the CD80 antigen. Galiximab (anti-CD80) has variable regions are primatized (cynomologous monkeys), and the constant regions are human. Galiximab (anti-CD80) can be used in research of B-cell lymphoma.

Product Properties

IsotypeHuman IgG1
Light Chain Typelambda
SDS-PAGE28.8 kDa (Light Chain) & 51.6 kDa (Heavy Chain), under reducing conditions; 183.4 kDa, under non-reducing conditions.
Purification MethodProtein A purified
Purity>95%
FormLiquid
ConcentrationLot by Lot
Storage TempStore at -80°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS357613-77-5

Images

Galiximab (anti-CD80) (Ab177850) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD80 (red) with Galiximab (anti-CD80) (Ab177850). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Galiximab (anti-CD80) (Ab177850) - SEC
The purity of Galiximab (anti-CD80) (Ab177850) is more than 95% verified by HPLC.

Associated Targets

CD80 Tclin T-lymphocyte activation antigen CD80 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot NumberCertificate TypeDateItem
ZJ23F1202072Certificate of AnalysisDec 20, 2023 Ab177850
ZJ23F1202073Certificate of AnalysisDec 20, 2023 Ab177850

Related Documents

References

1. Vicente Rabaneda EF, Herrero-Beaumont G, Castañeda S.  (2013)  Update on the use of abatacept for the treatment of rheumatoid arthritis..  Expert Rev Clin Immunol,  (7): (599-621).  [PMID:23899231]
2. Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA.  (1991)  CTLA-4 is a second receptor for the B cell activation antigen B7..  J Exp Med,  174  (3): (561-9).  [PMID:1714933]
3. Selvakumar, A A and 5 more authors..  (1992)  Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7..  Immunogenetics,      [PMID:1377173]
4. Freeman, G J GJ and 8 more authors..  (1991)  Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7..  The Journal of experimental medicine,    (1):   [PMID:1714935]
5. Freeman, G J GJ and 5 more authors..  (1989)  B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells..  Journal of immunology (Baltimore, Md. : 1950),    (15):   [PMID:2794510]
6. Lanier, L L LL and 7 more authors..  (1995)  CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL..  Journal of immunology (Baltimore, Md. : 1950),    (1):   [PMID:7527824]
7. Vandenborre, K K and 5 more authors..  (1999)  Interaction of CTLA-4 (CD152) with CD80 or CD86 inhibits human T-cell activation..  Immunology,      [PMID:10583602]
8. Ikemizu, S S and 7 more authors..  (2000)  Structure and dimerization of a soluble form of B7-1..  Immunity,      [PMID:10661405]
9. Stamper, C C CC and 9 more authors..  (2001)  Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses..  Nature,    (29):   [PMID:11279502]
10. Gottlieb, Alice B AB and 8 more authors..  (2004)  Evaluation of safety and clinical activity of multiple doses of the anti-CD80 monoclonal antibody, galiximab, in patients with moderate to severe plaque psoriasis..  Clinical immunology (Orlando, Fla.),      [PMID:15093549]
11. Czuczman, Myron S MS and 13 more authors..  (2005)  Phase I/II study of galiximab, an anti-CD80 antibody, for relapsed or refractory follicular lymphoma..  Journal of clinical oncology : official journal of the American Society of Clinical Oncology,    (1):   [PMID:15994148]
12. and Kremer, Joel M JM..  (2005)  Selective costimulation modulators: a novel approach for the treatment of rheumatoid arthritis..  Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases,      [PMID:16357751]
13. Hervey, Pauline S PS and Keam, Susan J SJ..  (2006)  Abatacept..  BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy,      [PMID:16573350]
14. Muzny, Donna M DM and 113 more authors..  (2006)  The DNA sequence, annotation and analysis of human chromosome 3..  Nature,    (27):   [PMID:16641997]
15. Weyand, Cornelia M CM and Goronzy, Jörg J JJ..  (2006)  T-cell-targeted therapies in rheumatoid arthritis..  Nature clinical practice. Rheumatology,      [PMID:16932686]
16. and Scheinfeld, Noah N..  (2006)  Abatacept: A review of a new biologic agent for refractory rheumatoid arthritis for dermatologists..  The Journal of dermatological treatment,      [PMID:16971318]
17. Tedesco Silva, Helio H, Pinheiro Machado, Paula P, Rosso Felipe, Claudia C and Medina Pestana, Jose Osmar JO..  (2006)  Immunotherapy for De Novo renal transplantation: what's in the pipeline?.  Drugs,      [PMID:16978033]
18. Vincenti, Flavio F and Luggen, Michael M..  (2007)  T cell costimulation: a rational target in the therapeutic armamentarium for autoimmune diseases and transplantation..  Annual review of medicine,      [PMID:17020493]
19. Nogid, Anna A and Pham, David Q DQ..  (2006)  Role of abatacept in the management of rheumatoid arthritis..  Clinical therapeutics,      [PMID:17212998]
20. Leonard, J P JP and 14 more authors..  (2007)  A phase I/II study of galiximab (an anti-CD80 monoclonal antibody) in combination with rituximab for relapsed or refractory, follicular lymphoma..  Annals of oncology : official journal of the European Society for Medical Oncology,      [PMID:17470451]
21. Kakoulidou, M M, Giscombe, R R, Zhao, X X, Lefvert, A K AK and Wang, X X..  (2007)  Human Soluble CD80 is generated by alternative splicing, and recombinant soluble CD80 binds to CD28 and CD152 influencing T-cell activation..  Scandinavian journal of immunology,      [PMID:17953528]
22. Reynolds, Jennifer J, Shojania, Kam K and Marra, Carlo A CA..  (2007)  Abatacept: a novel treatment for moderate-to-severe rheumatoid arthritis..  Pharmacotherapy,      [PMID:18041889]
23. Maxwell, Lara J LJ and Singh, Jasvinder A JA..  (2010)  Abatacept for rheumatoid arthritis: a Cochrane systematic review..  The Journal of rheumatology,      [PMID:20080922]
24. Kleinpeter, Patricia and 20 more authors..  (2019)  By Binding CD80 and CD86, the Vaccinia Virus M2 Protein Blocks Their Interactions with both CD28 and CTLA4 and Potentiates CD80 Binding to PD-L1..  Journal of virology,    (1):   [PMID:30918073]

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