Grouped product items

SKU

Size

Availability

Price

Qty

G106899-25mg

25mg

Available within 4-8 weeks(?)

$234.90

G106899-100mg

100mg

Available within 4-8 weeks(?)

$846.90

Basic Description

Synonyms	(-)-Gallocatechin gallate\|4233-96-9\|(-)-Gallocatechol gallate\|(2S,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate\|Gallocatechin gallate, (-)-\|(-)-gallocatechin-3-O-gallate\|(2S,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(
Specifications & Purity	≥98%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Product Description	An antioxidant

Associated Targets

DYRK1A Tchem Dual specificity tyrosine-phosphorylation-regulated kinase 1A 0 Activities

Discover Target: DYRK1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PSMB5 Tclin Proteasome subunit beta type-5 1 Activities

Discover Target: PSMB5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSP90AB1 Tchem Heat shock protein HSP 90-beta 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MET Tclin Hepatocyte growth factor receptor 0 Activities

Discover Target: MET

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SIRT6 Tchem NAD-dependent protein deacetylase sirtuin-6 0 Activities

Discover Target: SIRT6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SNCA Tchem Alpha-synuclein 0 Activities

Discover Target: SNCA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BCL2 Tclin Apoptosis regulator Bcl-2 1 Activities

Discover Target: BCL2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PGD Tchem 6-phosphogluconate dehydrogenase, decarboxylating 0 Activities

Discover Target: PGD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	[(2S,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
INCHI	InChI=1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21+/m1/s1
InChi Key	WMBWREPUVVBILR-NQIIRXRSSA-N
Canonical SMILES	C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
Isomeric SMILES	C1[C@H]([C@@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
WGK Germany	3
RTECS	DH9000000
PubChem CID	199472
Molecular Weight	458.37

Certificates

Certificate of Analysis(COA)

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1 results found

Lot Number	Certificate Type	Date	Item
F1903111	Certificate of Analysis	Mar 16, 2023	G106899

Chemical and Physical Properties

Sensitivity	light and Moisture sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	DH9000000

References

1. Y Sugita-Konishi,Y Hara-Kudo,F Amano,T Okubo,N Aoi,M Iwaki,S Kumagai. (1999-11-26) Epigallocatechin gallate and gallocatechin gallate in green tea catechins inhibit extracellular release of Vero toxin from enterohemorrhagic Escherichia coli O157:H7.. Biochimica et biophysica acta, 1472 ((1-2)): (42-50). [PMID:10572924]
2. Ikuo Ikeda,Makoto Kobayashi,Tadateru Hamada,Koichi Tsuda,Hitomi Goto,Katsumi Imaizumi,Ayumu Nozawa,Akio Sugimoto,Takami Kakuda. (2003-12-04) Heat-epimerized tea catechins rich in gallocatechin gallate and catechin gallate are more effective to inhibit cholesterol absorption than tea catechins rich in epigallocatechin gallate and epicatechin gallate.. Journal of agricultural and food chemistry, 51 ((25)): (7303-7307). [PMID:14640575]
3. Marlène Backleh-Sohrt,Perihan Ekici,Guenter Leupold,Harun Parlar. (2005-09-27) Efficiency of foam fractionation for the enrichment of nonpolar compounds from aqueous extracts of plant materials.. Journal of natural products, 68 ((9)): (1386-1389). [PMID:16180819]
4. Deniz Tasdemir,Gabriela Lack,Reto Brun,Peter Rüedi,Leonardo Scapozza,Remo Perozzo. (2006-05-26) Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.. Journal of medicinal chemistry, 49 ((11)): (3345-3353). [PMID:16722653]
5. Charles E Isaacs,Guang Y Wen,Weimin Xu,Jun Hua Jia,Lisa Rohan,Christopher Corbo,Vincenzo Di Maggio,Edmund C Jenkins,Sharon Hillier. (2008-01-16) Epigallocatechin gallate inactivates clinical isolates of herpes simplex virus.. Antimicrobial agents and chemotherapy, 52 ((3)): (962-970). [PMID:18195068]
6. Eui Seok Shin,Jiyoung Park,Jae-Min Shin,Dooho Cho,Si Young Cho,Dong Wook Shin,Mira Ham,Jae Bum Kim,Tae Ryong Lee. (2008-03-04) Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme.. Bioorganic & medicinal chemistry, 16 ((7)): (3580-3586). [PMID:18313308]
7. Sang Min Lee,Chae Wook Kim,Jung Kee Kim,Hyun Jung Shin,Joo Hyun Baik. (2008-03-28) GCG-rich tea catechins are effective in lowering cholesterol and triglyceride concentrations in hyperlipidemic rats.. Lipids, 43 ((5)): (419-429). [PMID:18365267]
8. José Antonio Curiel,Héctor Rodríguez,Iván Acebrón,José Miguel Mancheño,Blanca De Las Rivas,Rosario Muñoz. (2009-07-16) Production and physicochemical properties of recombinant Lactobacillus plantarum tannase.. Journal of agricultural and food chemistry, 57 ((14)): (6224-6230). [PMID:19601665]
9. Satoru Tamura,Kunichika Yoshihira,Katsuaki Fujiwara,Nobutoshi Murakami. (2010-03-06) New inhibitors for expression of IgE receptor on human mast cell.. Bioorganic & medicinal chemistry letters, 20 ((7)): (2299-2302). [PMID:20202836]
10. Yunbao Liu,Muraleedharan G Nair. (2010-06-23) An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.. Journal of natural products, 73 ((7)): (1193-1195). [PMID:20565070]
11. Fan Jiang,Wei Chen,Kejia Yi,Zhiqiang Wu,Yiling Si,Weidong Han,Yali Zhao. (2010-09-14) The evaluation of catechins that contain a galloyl moiety as potential HIV-1 integrase inhibitors.. Clinical immunology (Orlando, Fla.), 137 ((3)): (347-356). [PMID:20832370]
12. Noelia López-Gutiérrez,Roberto Romero-González,Patricia Plaza-Bolaños,José Luis Martínez Vidal,Antonia Garrido Frenich. (2014-12-04) Identification and quantification of phytochemicals in nutraceutical products from green tea by UHPLC-Orbitrap-MS.. Food chemistry, 173 (607-618). [PMID:25466066]
13. Zhonghua Liu,Yong Lin,Sheng Zhang,Die Wang,Qionglin Liang,Guoan Luo. (2015-06-04) Comparative proteomic analysis using 2DE-LC-MS/MS reveals the mechanism of Fuzhuan brick tea extract against hepatic fat accumulation in rats with nonalcoholic fatty liver disease.. Electrophoresis, 36 ((17)): (2002-2016). [PMID:26036873]
14. R J Aitken,L Muscio,S Whiting,H S Connaughton,B A Fraser,B Nixon,N D Smith,G N De Iuliis. (2016-09-24) Analysis of the effects of polyphenols on human spermatozoa reveals unexpected impacts on mitochondrial membrane potential, oxidative stress and DNA integrity; implications for assisted reproductive technology.. Biochemical pharmacology, 121 (78-96). [PMID:27659810]
15. Weidong Dai,Junfeng Tan,Meiling Lu,Yin Zhu,Pengliang Li,Qunhua Peng,Li Guo,Yue Zhang,Dongchao Xie,Zhengyan Hu,Zhi Lin. (2018-06-21) Metabolomics Investigation Reveals That 8-C N-Ethyl-2-pyrrolidinone-Substituted Flavan-3-ols Are Potential Marker Compounds of Stored White Teas.. Journal of agricultural and food chemistry, 66 ((27)): (7209-7218). [PMID:29921123]
16. Seyit Yuzuak,James Ballington,De-Yu Xie. (2018-09-29) HPLC-qTOF-MS/MS-Based Profiling of Flavan-3-ols and Dimeric Proanthocyanidins in Berries of Two Muscadine Grape Hybrids FLH 13-11 and FLH 17-66.. Metabolites, 8 ((4)): [PMID:30261603]
17. Liu, et al.. (2020) Rapid Screening ?-Glucosidase Inhibitors from Natural Products by At-Line Nanofractionation with Parallel Mass Spectrometry and Bioactivity Assessment.. Journal of Chromatography A, 1635 (461740-461740). [PMID:33271429]
18. Lifeng Cai,Miriam Gochin. (2007-04-25) A novel fluorescence intensity screening assay identifies new low-molecular-weight inhibitors of the gp41 coiled-coil domain of human immunodeficiency virus type 1.. Antimicrobial agents and chemotherapy, 51 ((7)): (2388-2395). [PMID:17452484]
19. Angelika S Rambold,Margit Miesbauer,Diana Olschewski,Ralf Seidel,Constanze Riemer,Lindsay Smale,Lisa Brumm,Michal Levy,Ehud Gazit,Dieter Oesterhelt,Michael Baier,Christian F W Becker,Martin Engelhard,Konstanze F Winklhofer,Jörg Tatzelt. (2008-08-12) Green tea extracts interfere with the stress-protective activity of PrP and the formation of PrP.. Journal of neurochemistry, 107 ((1)): (218-229). [PMID:18691383]
20. Christine A Larsen,William H Bisson,Roderick H Dashwood. (2009-10-21) Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies.. Journal of medicinal chemistry, 52 ((21)): (6543-6545). [PMID:19839593]
21. Pavel Svoboda,Hana Vlčková,Lucie Nováková. (2015-05-31) Development and validation of UHPLC-MS/MS method for determination of eight naturally occurring catechin derivatives in various tea samples and the role of matrix effects.. Journal of pharmaceutical and biomedical analysis, 114 (62-70). [PMID:26025813]

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(-)-Gallocatechin gallate - 98%, high purity , CAS No.4233-96-9