Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT)
Appearance:Solid
IC50& Target:Cx43 Hemichannel
In Vitro:Gap19 TFA (250 μM; for 30 min ) decreases mitochondrial potassium uptake. Gap19 TFA (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells. Gap19 TFA (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes. G
In Vivo:Gap19 TFA (iv; 25mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57/BL6 miceDosage:
Biological Activity:Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT)
Names and Identifiers
Molecular Weight
1275.46
Certificates
Certificate of Analysis(COA)
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Chemical and Physical Properties
Solubility
DMSO : 100 mg/mL (78.40 mM; Need ultrasonic) H2O : 100 mg/mL (78.40 mM; Need ultrasonic)
