GC-Globulin, Human Plasma, Mixed Type (Vitamin D Binding Protein)

Item Number

np001096

• Product Name: GC-Globulin, Human Plasma, Mixed Type (Vitamin D Binding Protein)
• Specifications & Purity: ≥95%(SDS-PAGE), Extinction Coefficient: 0.63
• Predicted molecular weight: 56,000Da

Product Description

An alpha 2 glycoprotein composed of a single polypeptide chain and present in plasma at levels of 20-55 mg/100 ml. It functions in the binding and transport of vitamin D and may also play an important role in actin homeostatis since it has been shown to bind monomeric actin with high affinity. GC-globulin also binds membranes of both circulating B and T lymphocytes. Clinically, concentrations are reduced in patients with severe liver diseases. GC-globulin may also play an important role in the mechanism of the osteomalacia that occurs with Itai-Itai disease.

Product Citations:
Trujillo, Glenda, David M. Habiel, Lingyin Ge, Mahalakshmi Ramadass, Nancy E. Cooke, and Richard R. Kew. "Neutrophil Recruitment to the Lung in Both C5a-and CXCL1-Induced Alveolitis Is Impaired in Vitamin D–Binding Protein-Deficient Mice." The Journal of Immunology (2013).

Ge, Lingyin, Glenda Trujillo, Edmund J. Miller, and Richard R. Kew. "Circulating Complexes of the Vitamin D Binding Protein with G-Actin Induce Lung Inflammation by Targeting Endothelial Cells." Immunobiology (2013).

Kilpatrick LE.
Optimizing High Resolution Mass Spectrometry for the Identification of Low Abundance Post-Translational Modifications of Intact Proteins.
J Proteome Res. 2017 Aug 8. doi: 10.1021/acs.jproteome.7b00244. [Epub ahead of print].

Ramadass M, Ghebrehiwet B, Kew RR.
Enhanced recognition of plasma proteins in a non-native state by complement C3b. A possible clearance mechanism for damaged proteins in blood.
Mol Immunol. 2015 Mar;64(1):55-62. doi: 10.1016/j.molimm.2014.10.022. Epub 2014 Nov 15.

Ramadass M, Ghebrehiwet B, Smith RJ, Kew RR.
Generation of Multiple Fluid-Phase C3b:Plasma Protein Complexes during Complement Activation: Possible Implications in C3 Glomerulopathies.
J Immunol. 2014 Feb 1;192(3):1220-30. doi: 10.4049/jimmunol.1302288. Epub 2013 Dec 23.