Nucleoside diphosphate used as a substrate of pyruvate kinase to produce GTP in support of RNA biosynthesis. Used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR).
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Guanosine 5′-diphosphate (GDP) is used as a substrate of pyruvate kinase to produce GTP in support of RNA biosyntheis. GDP is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). GDP is also used to study cell signaling processes mediate by guanine nucleotide exchange factors.
1.Guimei Wang, Xiaoxue Jiang, Nanyan Fu. (2019) Near-infrared squaraine fluorescent probe for imaging adenosine 5′-triphosphate in live cells. DYES AND PIGMENTS, 171 (107698). [PMID:][10.1016/j.dyepig.2019.107698]
References
1.Kutsch M et al.. (2020) Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions.. EMBO J, 39 (13):(e104926). [PMID:32510692]
2.Lattao R et al.. (2021) Mauve/LYST limits fusion of lysosome-related organelles and promotes centrosomal recruitment of microtubule nucleating proteins.. Dev Cell, [PMID:33725482]
3.Kumar S et al.. (2018) Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins.. J Cell Biol, 217 (3):(997-1013). [PMID:29420192]
4.Kovalski JR et al.. (2019) The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.. Mol Cell, 73 (4):(830-844.e12). [PMID:30639242]
5.Guimei Wang, Xiaoxue Jiang, Nanyan Fu. (2019) Near-infrared squaraine fluorescent probe for imaging adenosine 5′-triphosphate in live cells. DYES AND PIGMENTS, 171 (107698). [PMID:][10.1016/j.dyepig.2019.107698]
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