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gefapixant , P2X purinoceptor 3 antagonist, CAS No.G610541, P2X purinoceptor 3 antagonist

  • Moligand™
Item Number
G610541
Grouped product items
SKUSizeAvailabilityPrice Qty
G610541-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
G610541-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,001.90
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P2X3 Antagonist

Basic Description

SynonymsGefapixant|1015787-98-0|AF-219|Gefapixant [USAN]|RO4926219|Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-|RG-1646|Ro-4926219|6K6L7E3F1L|R-1646|AF219|Gefapixant(AF-219,MK-7264)|RG1646|5-[(2,4-diaminopyrimidin-5-yl)oxy]-
Specifications & PurityMoligand™
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionP2X purinoceptor 3 antagonist

Associated Targets

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

P2RX3 Tclin P2X purinoceptor 3 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

P2RX2 Tchem P2X purinoceptor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 5-(2,4-diaminopyrimidin-5-yl)oxy-2-methoxy-4-propan-2-ylbenzenesulfonamide
INCHI InChI=1S/C14H19N5O4S/c1-7(2)8-4-10(22-3)12(24(17,20)21)5-9(8)23-11-6-18-14(16)19-13(11)15/h4-7H,1-3H3,(H2,17,20,21)(H4,15,16,18,19)
InChi Key HLWURFKMDLAKOD-UHFFFAOYSA-N
Canonical SMILES COc1cc(C(C)C)c(cc1S(=O)(=O)N)Oc1cnc(nc1N)N
Isomeric SMILES CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)S(=O)(=O)N)OC
PubChem CID 24764487

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

References

1. Ford AP, Undem BJ.  (2013)  The therapeutic promise of ATP antagonism at P2X3 receptors in respiratory and urological disorders..  Front Cell Neurosci,  7  (3): (267).  [PMID:24391544]
2. Ochoa-Cortes F, Liñán-Rico A, Jacobson KA, Christofi FL.  (2014)  Potential for developing purinergic drugs for gastrointestinal diseases..  Inflamm Bowel Dis,  20  (7): (1259-87).  [PMID:24859298]
3. Richards D, Gever JR, Ford AP, Fountain SJ.  (2019)  Action of MK-7264 (gefapixant) at human P2X3 and P2X2/3 receptors and in vivo efficacy in models of sensitisation..  Br J Pharmacol,  176  (13): (2279-2291).  [PMID:30927255]
4. Markham A.  (2022)  Gefapixant: First Approval..  Drugs,  82  (6): (691-695).  [PMID:35347635]

Solution Calculators

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