Gliclazide - ≥99%, high purity , Sulfonylurea receptor 1, Kir6.2 blocker, CAS No.21187-98-4, Sulfonylurea receptor 1, Kir6.2 blocker

Item Number

G129571

• Synonyms: gliclazide|21187-98-4|Glimicron|1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea|1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea|CHEBI:31654|1-(Hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea|Gl
• Specifications & Purity: ≥99%
• Biochemical and Physiological Mechanisms: Gliclazide is a sulfonylurea hypoglycemic agent used as an antidiabetic.Selective sulfonylurea-1 (SUR-1) channel blocker (IC 50 values are 0.2 and 20 μM for SUR-1 and SUR-2A respectively). Stimulates insulin secretion by blocking ATP-sensitive K + channel
• Shipped In: Normal
• Action Type: BLOCKER
• Mechanism of action: Sulfonylurea receptor 1, Kir6.2 blocker
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.
Used in the treatment of non-insulin dependent diabetes mellitus (NIDDM).