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Glimepiride - ≥99%, high purity , CAS No.93479-97-1

Moligand™
≥99%

CAS#: 93479-97-1
Formula: C₂₄H₃₄N₄O₅S
Molecular Weight: 490.62
MDL number: MFCD00878417
PubChem CID: 3476

Item Number

G129354

Grouped product items
SKU	Size	Availability	Price
G129354-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$105.90
G129354-5g	5g	In stock	$462.90
G129354-25g	25g	In stock	$2,083.90

Potent cardiac K ATP channel blocker

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Pharmaceutical ingredients

Basic Description

Synonyms	glimepiride\|93479-97-1\|Amaryl\|Amarel\|Glimepirid\|Glimepirida\|Glimepiridum\|cis-Glimepiride\|Hoe-490\|684286-46-2\|Glimepride\|HOE 490\|Glimepiride, cis-\|GLIMPERIDE\|Glimepiride Impurity A\|CHEBI:5383\|1-((p-(2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl
Specifications & Purity	≥99%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Grade	Moligand™
Product Description	Glimepiride is a third generation sulfonylurea compound, which increases the release of insulin from pancreatic beta cells. In addition, Glimepiride increases the activity of intracellular insulin receptors. Studies conducted on adipocytes and skeletal muscle suggest that Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases protein expression of glucose transports 1 and 4, and is a potent KIR channel blocker. A third generation sulfonylurea compound that induces the PI3K and Akt pathway

Names and Identifiers

IUPAC Name	4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide
INCHI	InChI=1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)
InChi Key	WIGIZIANZCJQQY-UHFFFAOYSA-N
Canonical SMILES	CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C
Isomeric SMILES	CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C
WGK Germany	3
RTECS	UX9363950
PubChem CID	3476
Molecular Weight	490.62
Reaxy-Rn	7731873

DrugBank Ligand

PubChem CID

CAS Registry No.

ChEMBL Ligand

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2 results found

Lot Number	Certificate Type	Date	Item
K1901132	Certificate of Analysis	Jun 07, 2023	G129354
I1424185	Certificate of Analysis	May 07, 2022	G129354

Solubility

Soluble in DMSO (>10 mg/ml), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).

Melt Point(°C)

204 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H301:Toxic if swallowed H331:Toxic if inhaled H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P316:Get emergency medical help immediately.
WGK Germany	3
RTECS	UX9363950
Reaxy-Rn	7731873
Merck Index	4440

References

1. Miki T, Nagashima K, Seino S. (1999) The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells.. J Mol Endocrinol, 22 (2): (113-23). [PMID:10194514]
2. Rehmann H. (2012) Epac2: a sulfonylurea receptor?. Biochem Soc Trans, 40 (1): (6-10). [PMID:22260657]
3. Inagaki N, Gonoi T, Clement 4th JP, Namba N, Inazawa J, Gonzalez G, Aguilar-Bryan L, Seino S, Bryan J. (1995) Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.. Science, 270 (5239): (1166-70). [PMID:7502040]

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Glimepiride - ≥99%, high purity , CAS No.93479-97-1

Basic Description

Associated Targets

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Names and Identifiers

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