Glibenclamide is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production.
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Grade
Moligand™
Action Type
BLOCKER, CHANNEL BLOCKER, INHIBITOR
Mechanism of action
Sulfonylurea receptor 1, Kir6.2 blocker
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Glibenclamide(Glyburide) is a sulfonylurea compound that modulates insulin production. An ATP-dependent KIR6 and CFTR Cl- channel blocker
1.Miki T, Nagashima K, Seino S. (1999) The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells.. J Mol Endocrinol, 22 (2):(113-23). [PMID:10194514]
2.Lamkanfi M, Mueller JL, Vitari AC, Misaghi S, Fedorova A, Deshayes K, Lee WP, Hoffman HM, Dixit VM. (2009) Glyburide inhibits the Cryopyrin/Nalp3 inflammasome.. J Cell Biol, 187 (1):(61-70). [PMID:19805629]
3.Rehmann H. (2012) Epac2: a sulfonylurea receptor?. Biochem Soc Trans, 40 (1):(6-10). [PMID:22260657]
4.Gerzanich V, Makar TK, Guda PR, Kwon MS, Stokum JA, Woo SK, Ivanova S, Ivanov A, Mehta RI, Morris AB et al.. (2017) Salutary effects of glibenclamide during the chronic phase of murine experimental autoimmune encephalomyelitis.. J Neuroinflammation, 14 (1):(177). [PMID:28865458]
5.Inagaki N, Gonoi T, Clement 4th JP, Namba N, Inazawa J, Gonzalez G, Aguilar-Bryan L, Seino S, Bryan J. (1995) Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.. Science, 270 (5239):(1166-70). [PMID:7502040]
6.Wilkinson CM et al.. (2019) Glibenclamide, a Sur1-Trpm4 antagonist, does not improve outcome after collagenase-induced intracerebral hemorrhage.. PLoS One, 14 (5):(e0215952). [PMID:31042750]
7.Bragança B et al.. (2016) Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria.. Front Pharmacol, 7 (45). [PMID:27014060]
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