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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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G648030-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $400.90 | |
G648030-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $680.90 | |
G648030-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,350.90 |
Specifications & Purity | ≥98% |
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Biochemical and Physiological Mechanisms | GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor with an IC 50 of 38 nM for rGlyT1. Antipsychotic activity. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor with an IC 50 of 38 nM for rGlyT1 Antipsychotic activity In Vivo GlyT1 Inhibitor 1 (Compound 46) demonstrates in vivo efficacy in a rat novel object recognition (NOR) assay after oral dosing at 0.1, 1, and 3 mg/kg . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:rGlyT1 38 nM (IC 50 ) |
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IUPAC Name | 3-[2-(2-methylpyridin-4-yl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5-carbonyl]-4-propan-2-yloxybenzonitrile |
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INCHI | InChI=1S/C22H21N5O2/c1-14(2)29-21-5-4-16(10-23)9-19(21)22(28)26-11-17-12-27(25-20(17)13-26)18-6-7-24-15(3)8-18/h4-9,12,14H,11,13H2,1-3H3 |
InChi Key | CIEHAYBWEMOJMN-UHFFFAOYSA-N |
Canonical SMILES | CC1=NC=CC(=C1)N2C=C3CN(CC3=N2)C(=O)C4=C(C=CC(=C4)C#N)OC(C)C |
Isomeric SMILES | CC1=NC=CC(=C1)N2C=C3CN(CC3=N2)C(=O)C4=C(C=CC(=C4)C#N)OC(C)C |
PubChem CID | 118479295 |
Molecular Weight | 387.43 |
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Solubility | DMSO : 25 mg/mL (64.53 mM; ultrasonic and warming and heat to 60°C) |
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