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GNE-4997 , CAS No.G610615, Inhibitor of IL2 inducible T cell kinase

Item Number

G610615

Grouped product items
SKU	Size	Availability	Price	Qty
G610615-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
G610615-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	compound 28;GNE 4997;GNE4997
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of IL2 inducible T cell kinase

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

INCHI	InChI=1S/C25H27F2N5O3S/c1-24-12-18-17(11-20(24)25(24,26)27)21(31-30-18)23(33)29-16-13-28-32(14-16)22(15-7-3-2-4-8-15)19-9-5-6-10-36(19,34)35/h2-4,7-8,13-14,19-20,22H,5-6,9-12H2,1H3,(H,29,33)(H,30,31)/t19-,20-,22-,24+/m0/s1
InChi Key	JNRFIKALOWSUBG-CGCKEFBRSA-N
Canonical SMILES	O=C(c1n[nH]c2c1C[C@H]1[C@@](C2)(C1(F)F)C)Nc1cnn(c1)[C@H]([C@@H]1CCCCS1(=O)=O)c1ccccc1
PubChem CID	134611893

RCSB PDB Ligand	3P6
PubChem CID	134611893

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1. Burch JD, Barrett K, Chen Y, DeVoss J, Eigenbrot C, Goldsmith R, Ismaili MH, Lau K, Lin Z, Ortwine DF et al.. (2015) Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo.. J Med Chem, 58 (9): (3806-16). [PMID:25844760]

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