GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC 50 value of 13 nM for HEK-293 cell. GNE-6468 exhibits an EC 50 of 30 nM for IL-17 PBMC
In Vivo
GNE-6468 (compound 28) displays high predicted clearance values in human and rodent hepatocytes (CL hep = 17 and 42 mL/min/kg, respectively) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
