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GNE7915 - 98%, high purity , CAS No.1351761-44-8, Inhibitor of leucine rich repeat kinase 2;Inhibitor of TTK protein kinase

Moligand™
≥98%

CAS#: 1351761-44-8
Formula: C₁₉H₂₁F₄N₅O₃
Molecular Weight: 443.4
PubChem CID: 58539171

Item Number

G275946

Grouped product items
SKU	Size	Availability	Price
G275946-5mg	5mg	In stock	$48.90
G275946-10mg	10mg	In stock	$69.90
G275946-25mg	25mg	In stock	$140.90
G275946-50mg	50mg	In stock	$235.90
G275946-100mg	100mg	In stock	$400.90

Potent and selective, brain penetrant LRRK2 inhibitor.

View related series

leucine rich repeat kinase 2 Inhibitor TTK protein kinase Inhibitor

Basic Description

Synonyms	[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-methanone;(4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of leucine rich repeat kinase 2;Inhibitor of TTK protein kinase
Product Description	Shipped at room temperature. Store at -20°C.

Associated Targets

TTK Tchem Dual specificity protein kinase TTK 1 Activities

Discover Target: TTK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LRRK2 Tchem Leucine-rich repeat serine/threonine-protein kinase 2 6 Activities

Discover Target: LRRK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	[4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone
INCHI	InChI=1S/C19H21F4N5O3/c1-3-24-16-12(19(21,22)23)10-25-18(27-16)26-14-9-13(20)11(8-15(14)30-2)17(29)28-4-6-31-7-5-28/h8-10H,3-7H2,1-2H3,(H2,24,25,26,27)
InChi Key	XCFLWTZSJYBCPF-UHFFFAOYSA-N
Canonical SMILES	CCNC1=NC(=NC=C1C(F)(F)F)NC2=C(C=C(C(=C2)F)C(=O)N3CCOCC3)OC
Isomeric SMILES	CCNC1=NC(=NC=C1C(F)(F)F)NC2=C(C=C(C(=C2)F)C(=O)N3CCOCC3)OC
PubChem CID	58539171
Molecular Weight	443.4

CAS Registry No.

PubChem CID

ChEMBL Ligand

BindingDB Ligand

RCSB PDB Ligand

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
B2208154	Certificate of Analysis	Nov 15, 2022	G275946
B2208158	Certificate of Analysis	Nov 15, 2022	G275946
B2208162	Certificate of Analysis	Nov 15, 2022	G275946
B2208323	Certificate of Analysis	Nov 15, 2022	G275946
B2208352	Certificate of Analysis	Nov 15, 2022	G275946

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

References

1. Estrada AA, Liu X, Baker-Glenn C, Beresford A, Burdick DJ, Chambers M, Chan BK, Chen H, Ding X, DiPasquale AG et al.. (2012) Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.. J Med Chem, 55 (22): (9416-33). [PMID:22985112]
2. Estrada AA, Chan BK, Baker-Glenn C, Beresford A, Burdick DJ, Chambers M, Chen H, Dominguez SL, Dotson J, Drummond J et al.. (2014) Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.. J Med Chem, 57 (3): (921-36). [PMID:24354345]

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