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Go 6983 - ≥96%, high purity , CAS No.133053-19-7, Inhibitor of protein kinase C alpha;Inhibitor of protein kinase C beta;Inhibitor of protein kinase C delta;Inhibitor of protein kinase C gamma;Inhibitor of protein kinase C zeta

Specifications & Purity: ≥96%

CAS#: 133053-19-7
Formula: C₂₆H₂₆N₄O₃
Molecular Weight: 442.51
PubChem CID: 3499

Item Number

G129385

Grouped product items
SKU	Size	Availability	Price
G129385-1mg	1mg	In stock	$24.90
G129385-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$103.90
G129385-10mg	10mg	In stock	$169.90
G129385-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$382.90
G129385-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$900.90

Potent, fast-acting, broad spectrum PKC inhibitor

View related series

protein kinase C alpha Inhibitor protein kinase C beta Inhibitor protein kinase C delta Inhibitor protein kinase C gamma Inhibitor protein kinase C zeta Inhibitor

Basic Description

Synonyms	go 6983\|133053-19-7\|Go6983\|Goe 6983\|3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione\|Go-6983\|3-(1-(3-(dimethylamino)propyl)-5-methoxy-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione\|Go-6893\|G? 6983\|3-[1-
Specifications & Purity	≥96%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Action Type	INHIBITOR
Mechanism of action	Inhibitor of protein kinase C alpha;Inhibitor of protein kinase C beta;Inhibitor of protein kinase C delta;Inhibitor of protein kinase C gamma;Inhibitor of protein kinase C zeta

Associated Targets

PRKCZ Tchem Protein kinase C zeta type 1 Activities

Discover Target: PRKCZ

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKCD Tclin Protein kinase C delta type 1 Activities

Discover Target: PRKCD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKCB Tchem Protein kinase C beta type 1 Activities

Discover Target: PRKCB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKCG Tchem Protein kinase C gamma type 1 Activities

Discover Target: PRKCG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKCA Tchem Protein kinase C alpha type 1 Activities

Discover Target: PRKCA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-[1-[3-(dimethylamino)propyl]-5-methoxyindol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
INCHI	InChI=1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)
InChi Key	LLJJDLHGZUOMQP-UHFFFAOYSA-N
Canonical SMILES	CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
Isomeric SMILES	CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
WGK Germany	3
PubChem CID	3499
Molecular Weight	442.51

CAS Registry No.

133053-19-7

PubChem CID

3499

ChEMBL Ligand

CHEMBL261491

Certificates

Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
G2110297	Certificate of Analysis	Apr 18, 2023	G129385
G2110298	Certificate of Analysis	Apr 18, 2023	G129385

Pictogram(s)

GHS07

Signal

Warning

Hazard Statements

H315,H319,H335

Precautionary Statements

P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

WGK Germany

References

1. Gschwendt M, Dieterich S, Rennecke J, Kittstein W, Mueller HJ, Johannes FJ. (1996) Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes.. FEBS Lett, 392 (2): (77-80). [PMID:8772178]
2. Kataura T et al.. (2020) A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.. Autophagy, (1-17). [PMID:32762399]
3. König B et al.. (2019) A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength.. Elife, 8 [PMID:31210638]
4. Toufaily C et al.. (2021) Addition of a carboxy-terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice.. Elife, 10 [PMID:34939930]
5. D'Souza RS et al.. (2020) Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex.. Elife, 9 [PMID:32234213]
6. Barakat TS et al.. (2018) Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells.. Cell Stem Cell, 23 (2): (276-288.e8). [PMID:30033119]
7. De Virgiliis F et al.. (2020) Enriched conditioning expands the regenerative ability of sensory neurons after spinal cord injury via neuronal intrinsic redox signaling.. Nat Commun, 11 (6425). [PMID:33349630]
8. Lv G et al.. (2020) Inhibition of carrageenan-induced dental inflammatory responses owing to decreased TRPV1 activity by Dexmedetomidine.. J Inflamm (Lond), 17 (18). [PMID:32377171]
9. Nguyen GT et al.. (2020) SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst.. Elife, 9 [PMID:32352382]

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