| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| G486044-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,523.90 |
| Specifications & Purity | 20nm diameter, carboxylic acid functionalized, PEG 3000 coated, OD 50, dispersion in H₂O |
|---|---|
| Storage Temp | Store at 2-8°C |
| Shipped In | Wet ice |
| Product Description | Description Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and reduce aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating was possible on smaller AuNPs. Carboxylic acid functionalized GNPs form conjugates with various protein molecules due to the electrostatic attraction between the negatively charged carboxylate groups and positively charged amino groups of protein. Since it adheres to cell membranes, it may find use in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.Several other specific applications have been listed below:Since they adhere to cell membranes, AuNPs may find use in cellular and intracellular targeting in targeted drug delivery applications and may also be used in biodistribution studies.AuNPs may also be used in photothermal therapy and radiotherapy.AuNPs ranging from 10 to 250 nm, were studied to have been absorbed primarily by liver and spleen, when injected intravenously in rats.Whereas, 10 nm nanoparticles were distributed more broadly into various organs.Carboxylic acid end-groups bind with various proteins and hence are used in targeted drug delivery and gene therapy.Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery. |
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| Solubility | water: miscible |
|---|
| 1. Nishima Wangoo, K K Bhasin, S K Mehta, C Raman Suri,. (2008-05-20) Synthesis and capping of water-dispersed gold nanoparticles by an amino acid: bioconjugation and binding studies.. Journal of colloid and interface science, 323 ((2)): ( 247-254 ). [PMID:18486946] |
| 2. Sarah D Brown,Paola Nativo,Jo-Ann Smith,David Stirling,Paul R Edwards,Balaji Venugopal,David J Flint,Jane A Plumb,Duncan Graham,Nial J Wheate. (2010-03-17) Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin.. Journal of the American Chemical Society, 132 ((13)): (4678-4684). [PMID:20225865] |
| 3. Xiao-Dong Zhang,Di Wu,Xiu Shen,Pei-Xun Liu,Na Yang,Bin Zhao,Hao Zhang,Yuan-Ming Sun,Liang-An Zhang,Fei-Yue Fan. (2011-10-07) Size-dependent in vivo toxicity of PEG-coated gold nanoparticles.. International journal of nanomedicine, 6 (2071-2081). [PMID:21976982] |
| 4. Timothy A Larson, Pratixa P Joshi, Konstantin Sokolov,. (2012-09-27) Preventing protein adsorption and macrophage uptake of gold nanoparticles via a hydrophobic shield.. ACS nano, 6 ((10)): ( 9182-9190 ). [PMID:23009596] |
| 5. Alexandre Albanese,Warren C W Chan. (2011-06-23) Effect of gold nanoparticle aggregation on cell uptake and toxicity.. ACS nano, 5 ((7)): (5478-5489). [PMID:21692495] |
