Carboxylic acid functionalized, PEG 5000 coated and H2O dispersed gold nanoparticles (5 nm) can be potentially used in the development of biosensors, cancer-cell imaging, drug delivery, and photothermal therapy.AuNPs may be used to prepare SARS-CoV-2 conjugate for COVID-19 detection using lateral flow immunoassay technique. It may also be used in immobilization of antibodies to improve the sensitivity of optical fiber sensors for the screening of COVID-19. It can also be deposited on the titanium electrode for the formation of a miniaturized device for the electrochemical detection of DNA hybridization.Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.
1.Nishima Wangoo, K K Bhasin, S K Mehta, C Raman Suri,. (2008-05-20) Synthesis and capping of water-dispersed gold nanoparticles by an amino acid: bioconjugation and binding studies.. Journal of colloid and interface science, 323 ((2)):( 247-254 ). [PMID:18486946]
2.Sarah D Brown,Paola Nativo,Jo-Ann Smith,David Stirling,Paul R Edwards,Balaji Venugopal,David J Flint,Jane A Plumb,Duncan Graham,Nial J Wheate. (2010-03-17) Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin.. Journal of the American Chemical Society, 132 ((13)):(4678-4684). [PMID:20225865]
3.Jennifer Mytych,Anna Lewinska,Jacek Zebrowski,Maciej Wnuk. (2015-07-23) Gold Nanoparticles Promote Oxidant-Mediated Activation of NF-κB and 53BP1 Recruitment-Based Adaptive Response in Human Astrocytes.. BioMed research international, 2015 (304575-304575). [PMID:26199937]
4.Alexandre Albanese,Warren C W Chan. (2011-06-23) Effect of gold nanoparticle aggregation on cell uptake and toxicity.. ACS nano, 5 ((7)):(5478-5489). [PMID:21692495]
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