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Grapiprant (CJ-023,423) - 98%, high purity , CAS No.415903-37-6, Antagonist of EP 4 receptor
Basic Description Synonyms Grapiprant|415903-37-6|CJ-023423|AAT-007|RQ-00000007|N-((4-(2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenethyl)carbamoyl)-4-methylbenzenesulfonamide|CJ 023423|CJ-023|CJ-023,423|RQ-7|MR-10A7|UNII-J9F5ZPH7NB|J9F5ZPH7NB|MR10A7|Grapiprant (CJ-023423 Specifications & Purity Moligand™, ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of EP 4 receptor Product Description Grapiprant (CJ-023,423, AT-001, AAT-007, RQ-00000007, CJ-23423) is a novel selective EP4 Prostaglandin Receptor inhibitor with Ki of 20 nM and 13 nM for rat EP4 receptor and human EP4 receptor, respectively.
Names and Identifiers IUPAC Name 1-[2-[4-(2-ethyl-4,6-dimethylimidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea INCHI InChI=1S/C26H29N5O3S/c1-5-24-29-25-19(4)28-18(3)16-23(25)31(24)21-10-8-20(9-11-21)14-15-27-26(32)30-35(33,34)22-12-6-17(2)7-13-22/h6-13,16H,5,14-15H2,1-4H3,(H2,27,30,32) InChi Key HZVLFTCYCLXTGV-UHFFFAOYSA-N Canonical SMILES CCC1=NC2=C(N1C3=CC=C(C=C3)CCNC(=O)NS(=O)(=O)C4=CC=C(C=C4)C)C=C(N=C2C)C Isomeric SMILES CCC1=NC2=C(N1C3=CC=C(C=C3)CCNC(=O)NS(=O)(=O)C4=CC=C(C=C4)C)C=C(N=C2C)C PubChem CID 11677589 Molecular Weight 491.61
References 1. Nakao K, Murase A, Ohshiro H, Okumura T, Taniguchi K, Murata Y, Masuda M, Kato T, Okumura Y, Takada J. (2007) CJ-023,423, a novel, potent and selective prostaglandin EP4 receptor antagonist with antihyperalgesic properties.. J Pharmacol Exp Ther, 322 (2): (686-94). [PMID:17495127 ]
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