The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
GS 441524 - ≥98%(HPLC), high purity , CAS No.1191237-69-0
Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucelotide
Basic Description Synonyms 1191237-69-0|GS-441524|GS441524|(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile|GS 441524|EVO984|EVO-984|(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(h Specifications & Purity ≥98%(HPLC) Storage Temp Store at -20°C,Argon charged Shipped In Ice chest + Ice pads Grade Moligand™
Names and Identifiers IUPAC Name (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile INCHI InChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1 InChi Key BRDWIEOJOWJCLU-LTGWCKQJSA-N Canonical SMILES C1=C2C(=NC=NN2C(=C1)C3(C(C(C(O3)CO)O)O)C#N)N Isomeric SMILES C1=C2C(=NC=NN2C(=C1)[C@]3([C@@H]([C@@H]([C@H](O3)CO)O)O)C#N)N Alternate CAS 1191237-69-0 PubChem CID 44468216 MeSH Entry Terms (13C3)-GS-441524;(2R,3R,4S,5R)-2-(4-Aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furancarbonitrile;13C3 GS-441524;13C3-GS-441524;2-C-(4-Aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-2,5-anhydro-D-altrononitrile;GS 441524;G Molecular Weight 291.27
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 29.13, Max Conc. mM: 100
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
References 1. Li Y, Cao L, Li G, Cong F, Li Y, Sun J, Luo Y, Chen G, Li G, Wang P et al. . (2021) Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models.. J Med Chem, 129 (3): (589-97). [PMID:33523654 ]
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
A2405495