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STE:Homologs of yeast Sterile 7, Sterile 11, Sterile 20 kinases
GS-444217 , CAS No.G610676, Inhibitor of mitogen-activated protein kinase kinase kinase 5

GS-444217 , CAS No.G610676, Inhibitor of mitogen-activated protein kinase kinase kinase 5

Item Number

G610676

Grouped product items
SKU	Size	Availability	Price	Qty
G610676-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
G610676-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

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Basic Description

Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of mitogen-activated protein kinase kinase kinase 5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	4-(4-cyclopropylimidazol-1-yl)-N-[3-(4-cyclopropyl-1,2,4-triazol-3-yl)phenyl]pyridine-2-carboxamide
INCHI	InChI=1S/C23H21N7O/c31-23(20-11-19(8-9-24-20)29-12-21(25-13-29)15-4-5-15)27-17-3-1-2-16(10-17)22-28-26-14-30(22)18-6-7-18/h1-3,8-15,18H,4-7H2,(H,27,31)
InChi Key	ZGCMQKWOUIMBEP-UHFFFAOYSA-N
Canonical SMILES	O=C(c1nccc(c1)n1cnc(c1)C1CC1)Nc1cccc(c1)c1nncn1C1CC1
Isomeric SMILES	C1CC1C2=CN(C=N2)C3=CC(=NC=C3)C(=O)NC4=CC=CC(=C4)C5=NN=CN5C6CC6
PubChem CID	57504987

PubChem CID	57504987
RCSB PDB Ligand	S0L

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1. Tesch GH, Ma FY, Han Y, Liles JT, Breckenridge DG, Nikolic-Paterson DJ. (2015) ASK1 Inhibitor Halts Progression of Diabetic Nephropathy in Nos3-Deficient Mice.. Diabetes, 64 (11): (3903-13). [PMID:26180085]
2. Budas GR, Boehm M, Kojonazarov B, Viswanathan G, Tian X, Veeroju S, Novoyatleva T, Grimminger F, Hinojosa-Kirschenbaum F, Ghofrani HA et al.. (2018) ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension.. Am J Respir Crit Care Med, 197 (3): (373-385). [PMID:28910144]

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