GSK 1070806 (anti-IL-18) is a fully humanized, high-affinity monoclonal antibody targeting IL-18. It has the potential for the treatment of autoinflammatory diseases research, including adult-onset Still’s disease (AOSD).
Product Properties
Isotype
Human IgG1
Light Chain Type
kappa
SDS-PAGE
26.5 kDa (Light Chain) & 53.7 kDa (Heavy Chain), under reducing conditions; 189.6 kDa, under non-reducing conditions.
Purification Method
Protein A purified
Purity
>95%
Form
Liquid
Concentration
Lot by Lot
Storage Temp
Store at -80°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
Images
GSK 1070806 (anti-IL-18) (Ab177855) - ELISA Immobilized Recombinant Human IL-18 Protein (rp147444) at 2.0 μg/mL can bind GSK 1070806 (anti-IL-18) (Ab177855) with the EC₅₀ of 187.6 ng/mL.
GSK 1070806 (anti-IL-18) (Ab177855) - SEC The purity of GSK 1070806 (anti-IL-18) (Ab177855) is more than 95% verified by HPLC.
1.Ushio, S S and 15 more authors.. (1996) Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein.. Journal of immunology (Baltimore, Md. : 1950), (1):[PMID:8666798]
2.Tominaga, K K and 7 more authors.. (2000) IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells.. International immunology, [PMID:10653850]
3.Kato, Zenichiro Z and 14 more authors.. (2003) The structure and binding mode of interleukin-18.. Nature structural biology, [PMID:14528293]
4.Gaggero, Alessia A and 7 more authors.. (2004) A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing.. Oncogene, (30):[PMID:15326478]
5.Jourdan, Tony T and 13 more authors.. (2013) Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.. Nature medicine, [PMID:23955712]
6.Wei, Hui H and 6 more authors.. (2014) Structural basis for the specific recognition of IL-18 by its alpha receptor.. FEBS letters, (3):[PMID:25261253]
7.Tsutsumi, Naotaka N and 12 more authors.. (2014) The structural basis for receptor recognition of human interleukin-18.. Nature communications, (15):[PMID:25500532]
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