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GSK 1070806 (anti-IL-18) - Primary antibody, specific to IL18, >95%, high purity, Human IgG1

  • Azide Free
  • Carrier Free
  • ExactAb™
  • Low Endotoxin
  • Recombinant
  • Validated
  • ≥95%(SDS-PAGE&SEC)
  • Lot by Lot
Features and benefits
  • Short Overview:

    Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

  • Species reactivity(Reacts with): Cynomolgus monkey,Human,Rhesus monkey
  • Isotype: Human IgG1
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
Item Number
Ab177855
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab177855-100μg
100μg
In stock
$109.90
Ab177855-1mg
1mg
In stock
$519.90
Ab177855-5mg
5mg
In stock
$1,399.90
Ab177855-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,239.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product NameGSK 1070806 (anti-IL-18) - Primary antibody, specific to IL18, >95%, high purity, Human IgG1
SynonymsIboctadekin antibody; IFN gamma inducing factor antibody; IFN-gamma-inducing factor antibody; IGIF antibody; IL 1 gamma antibody; IL 18 antibody; IL 1g antibody; IL-1 gamma antibody; IL-18 antibody; IL1 gamma antibody; IL18 antibody; IL18 protein antibody
Specifications & PurityExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
SpecificityIL18
ConjugationUnconjugated
GradeAzide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Product Description

GSK 1070806 (anti-IL-18) is a fully humanized, high-affinity monoclonal antibody targeting IL-18. It has the potential for the treatment of autoinflammatory diseases research, including adult-onset Still’s disease (AOSD).

Product Properties

IsotypeHuman IgG1
Light Chain Typekappa
SDS-PAGE26.5 kDa (Light Chain) & 53.7 kDa (Heavy Chain), under reducing conditions; 189.6 kDa, under non-reducing conditions.
Purification MethodProtein A purified
Purity>95%
FormLiquid
ConcentrationLot by Lot
Storage TempStore at -80°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

GSK 1070806 (anti-IL-18) (Ab177855) - ELISA
Immobilized Recombinant Human IL-18 Protein (rp147444) at 2.0 μg/mL can bind GSK 1070806 (anti-IL-18) (Ab177855) with the EC₅₀ of 187.6 ng/mL.

GSK 1070806 (anti-IL-18) (Ab177855) - SEC
The purity of GSK 1070806 (anti-IL-18) (Ab177855) is more than 95% verified by HPLC.

Associated Targets

IL18 Tbio Interleukin-18 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot NumberCertificate TypeDateItem
ZJ24F0404169Certificate of AnalysisApr 07, 2024 Ab177855
ZJ24F0404168Certificate of AnalysisApr 07, 2024 Ab177855
ZJ24F0404167Certificate of AnalysisApr 07, 2024 Ab177855

Related Documents

References

1. Ushio, S S and 15 more authors..  (1996)  Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein..  Journal of immunology (Baltimore, Md. : 1950),    (1):   [PMID:8666798]
2. Tominaga, K K and 7 more authors..  (2000)  IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells..  International immunology,      [PMID:10653850]
3. Kato, Zenichiro Z and 14 more authors..  (2003)  The structure and binding mode of interleukin-18..  Nature structural biology,      [PMID:14528293]
4. Gaggero, Alessia A and 7 more authors..  (2004)  A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing..  Oncogene,    (30):   [PMID:15326478]
5. Jourdan, Tony T and 13 more authors..  (2013)  Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes..  Nature medicine,      [PMID:23955712]
6. Wei, Hui H and 6 more authors..  (2014)  Structural basis for the specific recognition of IL-18 by its alpha receptor..  FEBS letters,    (3):   [PMID:25261253]
7. Tsutsumi, Naotaka N and 12 more authors..  (2014)  The structural basis for receptor recognition of human interleukin-18..  Nature communications,    (15):   [PMID:25500532]

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