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GSK-1838705A , CAS No.1186659-59-5, Inhibitor of ALK receptor tyrosine kinase;Inhibitor of Insulin-like growth factor I receptor;Inhibitor of Insulin receptor;Inhibitor of ribosomal protein S6 kinase A1

Moligand™

CAS#: 1186659-59-5
Formula: C₂₇H₂₇FN₈O₃
Molecular Weight: 530.55
PubChem CID: 25113169

Item Number

G610695

Grouped product items
SKU	Size	Availability	Price	Qty
G610695-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,715.90
G610695-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$6,000.90

View related series

ALK receptor tyrosine kinase Inhibitor Insulin receptor Inhibitor Insulin-like growth factor I receptor Inhibitor ribosomal protein S6 kinase A1 Inhibitor

Basic Description

Synonyms	1186659-59-5\|no finder\|W6545R69M8\|Benzamide, 2-((2-((1-(2-(dimethylamino)acetyl)-5-methoxy-1H-indol-6-yl)amino)-7H-pyrrolo(2,3-d)pyrimidin-4-yl)amino)-6-fluoro-N-methyl-\|2-[(2-{[1-(N,N-Dimethylglycyl)-5-Methoxy-1h-Indol-6-Yl]amino}-7h-Pyrrolo[2,3-D]pyrimi
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of ALK receptor tyrosine kinase;Inhibitor of Insulin-like growth factor I receptor;Inhibitor of Insulin receptor;Inhibitor of ribosomal protein S6 kinase A1

Associated Targets

IGF1R Tclin Insulin-like growth factor 1 receptor 2 Activities

Discover Target: IGF1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RPS6KA1 Tchem Ribosomal protein S6 kinase alpha-1 1 Activities

Discover Target: RPS6KA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALK Tclin ALK tyrosine kinase receptor 1 Activities

Discover Target: ALK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

INSR Tclin Insulin receptor 1 Activities

Discover Target: INSR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-[[2-[[1-[2-(dimethylamino)acetyl]-5-methoxyindol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methylbenzamide
INCHI	InChI=1S/C27H27FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-13H,14H2,1-4H3,(H,29,38)(H3,30,31,32,33,34)
InChi Key	DESOLSKAHZZIGK-UHFFFAOYSA-N
Canonical SMILES	CNC(=O)C1=C(C=CC=C1F)NC2=NC(=NC3=C2C=CN3)NC4=C(C=C5C=CN(C5=C4)C(=O)CN(C)C)OC
Isomeric SMILES	CNC(=O)C1=C(C=CC=C1F)NC2=NC(=NC3=C2C=CN3)NC4=C(C=C5C=CN(C5=C4)C(=O)CN(C)C)OC
PubChem CID	25113169
Molecular Weight	530.55

CAS Registry No.

DiscoveRx TREEspot

PubChem CID

ChEMBL Ligand

References

1. Sabbatini P, Korenchuk S, Rowand JL, Groy A, Liu Q, Leperi D, Atkins C, Dumble M, Yang J, Anderson K et al.. (2009) GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers.. Mol Cancer Ther, 8 (10): (2811-20). [PMID:19825801]

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