| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| G654662-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $275.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Dry ice |
| Product Description | GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1) . GSK-3484862 induces DNA hypomethylation to against cancer . GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity In Vitro GSK-3484862 (0-10 µM, 6 or 14 days) induces dramatic DNA methylation loss. GSK-3484862 (0-10 µM, 4 days) results in a modest reduction in DNMT1 protein level. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Murine embryonic stem cells (mESC, wild-type (WT) or Dnmt1/3a/3b triple knockout (TKO)) Concentration: 2 µM and 10 µM Incubation Time: 6 or 14 days Result: Induced dramatic DNA methylation loss, with global CpG methylation levels falling from near 70% in WT mESC to less than 18% after 6 days. Western Blot AnalysisCell Line: Murine embryonic stem cells (mESC, wild-type (WT) or Dnmt1/3a/3b triple knockout (TKO)) Concentration: 2 µM and 10 µM Incubation Time: 4 days Result: Resulted in a modest reduction in DNMT1 protein level. IC50& Target:DNMT1 |
| Canonical SMILES | CCC1=C(C(=NC(=C1C#N)SC(C2=CC=CC=C2)C(=O)N)N(C)C)C#N |
|---|---|
| Molecular Weight | 365.45 |
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