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GSK1482160 , CAS No.1001389-72-5, Allosteric modulator of P2X7;Antagonist of P2X7

Moligand™

CAS#: 1001389-72-5
PubChem CID: 23649427

Item Number

G610688

Grouped product items
SKU	Size	Availability	Price	Qty
G610688-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
G610688-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

View related series

P2X7 Allosteric modulator P2X7 Antagonist

Basic Description

Synonyms	GSK-1482160\|GSK1482160\|T1V3OH20HG\|UNII-T1V3OH20HG\|CHEMBL1222883\|2-Pyrrolidinecarboxamide, N-((2-chloro-3-(trifluoromethyl)phenyl)methyl)-1-methyl-5-oxo-, (2S)-\|1001389-72-5\|SCHEMBL2581415\|GTPL10504\|BJEMSIVBBUBXMZ-JTQLQIEISA-N\|BDBM50416603\|compound 1b [PMI
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR, ANTAGONIST
Mechanism of action	Allosteric modulator of P2X7;Antagonist of P2X7

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Discover Target: CYP2C19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

P2RX7 Tchem P2X purinoceptor 7 7 Activities

Discover Target: P2RX7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

INCHI	InChI=1S/C14H14ClF3N2O2/c1-20-10(5-6-11(20)21)13(22)19-7-8-3-2-4-9(12(8)15)14(16,17)18/h2-4,10H,5-7H2,1H3,(H,19,22)/t10-/m0/s1
InChi Key	BJEMSIVBBUBXMZ-JTQLQIEISA-N
Canonical SMILES	CN1C(=O)CC[C@H]1C(=O)NCc1cccc(c1Cl)C(F)(F)F
Isomeric SMILES	CN1[C@@H](CCC1=O)C(=O)NCC2=C(C(=CC=C2)C(F)(F)F)Cl
PubChem CID	23649427

PubChem CID

ChEMBL Ligand

CAS Registry No.

BindingDB Ligand

References

1. Abdi MH, Beswick PJ, Billinton A, Chambers LJ, Charlton A, Collins SD, Collis KL, Dean DK, Fonfria E, Gleave RJ et al.. (2010) Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor.. Bioorg Med Chem Lett, 20 (17): (5080-4). [PMID:20673717]

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