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GSK2256294 , Epoxide hydratase inhibitor, CAS No.G610702, Epoxide hydratase inhibitor
Basic Description Synonyms GSK2256294A|1142090-23-0|GSK2256294|GSK-2256294|GSK-2256294A|GSK 2256294A|GSK 2256294|L33EX3XR0T|cis-N-((4-Cyano-2-(trifluoromethyl)phenyl)methyl)-3-((4-methyl-6-(methylamino)-1,3,5-triazin-2-yl)amino)cyclohexanecarboxamide|CHEMBL3818875|(1R,3S)-N-(4-cyan Specifications & Purity Moligand™, ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Epoxide hydratase inhibitor Product Description
GSK2256294A (GSK 2256294) is a selective and orally active inhibitor of soluble epoxide hydrolase (sEH). GSK2256294A inhibits recombinant human sEH, rat sEH orthologs and murine sEH orthologs with IC50s of 27, 61 and 189 pM, respectively. GSK2256294A can be used for the research of chronic obstructive pulmonary disease (COPD) and cardiovascular disease
Names and Identifiers IUPAC Name (1R,3S)-N-[[4-cyano-2-(trifluoromethyl)phenyl]methyl]-3-[[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]amino]cyclohexane-1-carboxamide INCHI InChI=1S/C21H24F3N7O/c1-12-28-19(26-2)31-20(29-12)30-16-5-3-4-14(9-16)18(32)27-11-15-7-6-13(10-25)8-17(15)21(22,23)24/h6-8,14,16H,3-5,9,11H2,1-2H3,(H,27,32)(H2,26,28,29,30,31)/t14-,16+/m1/s1 InChi Key LQHDJQIMETZMPH-ZBFHGGJFSA-N Canonical SMILES CC1=NC(=NC(=N1)NC2CCCC(C2)C(=O)NCC3=C(C=C(C=C3)C#N)C(F)(F)F)NC Isomeric SMILES CC1=NC(=NC(=N1)N[C@H]2CCC[C@H](C2)C(=O)NCC3=C(C=C(C=C3)C#N)C(F)(F)F)NC PubChem CID 59448236 Molecular Weight 447.46
Chemical and Physical Properties Solubility DMSO: 45 mg/mL (100.57 mM)
References 1. Spector AA, Norris AW. (2007) Action of epoxyeicosatrienoic acids on cellular function.. Am J Physiol, Cell Physiol, 292 (3): (C996-1012). [PMID:16987999 ] 2. Spector AA, Fang X, Snyder GD, Weintraub NL. (2004) Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.. Prog Lipid Res, 43 (1): (55-90). [PMID:14636671 ] 3. Lazaar AL, Yang L, Boardley RL, Goyal NS, Robertson J, Baldwin SJ, Newby DE, Wilkinson IB, Tal-Singer R, Mayer RJ et al. . (2016) Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor.. Br J Clin Pharmacol, 81 (5): (971-9). [PMID:26620151 ]
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