GSK3735967 - 99%, high purity , CAS No.2170136-86-2

Item Number

G647419

Grouped product items
SKU	Size	Availability	Price
G647419-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$300.90
G647419-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$450.90
G647419-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$950.90
G647419-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,500.90

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Basic Description

Specifications & Purity	99%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Product Description	GSK3735967 is an selective, reversible, non-nucleoside inhibitor of DNMT1 with an IC 50 value of 40 nM. GSK3735967 contains a planar dicyanopyridine core that can specifically embed DNMT1 bound hemimethylated CpG dinucleotides. GSK3735967 has three binding sites, one of which can bind to histone H4K20me3. In Vitro GSK3735967 (0.1-10000 nM) inhibits the activity of DNMT1 in a dose dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

Canonical SMILES

N#CC1=C(SCC2=CC=C(CNC(CN)=O)C=C2)N=C(N3CCN(CCC3)C)C(C#N)=C1CC

Molecular Weight

477.62

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Basic Description