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GSK417651A , CAS No.G610721, Channel blocker of TRPC3;Channel blocker of TRPC6

Moligand™

PubChem CID: 1096735

Item Number

G610721

Grouped product items
SKU	Size	Availability	Price	Qty
G610721-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$572.90
G610721-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

TRPC3 Channel blocker TRPC6 Channel blocker

Basic Description

Synonyms	GSK417651A\|736945-96-3\|WV82DEG4YA\|GSK-417651A\|UNII-WV82DEG4YA\|MLS000718305\|TRPC3/6-IN-1\|3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanilino)-1,3-thiazol-4-yl]methanone\|SMR000290573\|(3,4-Dihydro-2(1H)-isoquinolinyl)(2-((4-methoxyphenyl)amino)-4-thiazolyl)
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of TRPC3;Channel blocker of TRPC6

Associated Targets

CBX1 Tbio Chromobox protein homolog 1 0 Activities

Discover Target: CBX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GMNN Tbio Geminin 0 Activities

Discover Target: GMNN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MDM2 Tchem E3 ubiquitin-protein ligase Mdm2 0 Activities

Discover Target: MDM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPC3 Tchem Short transient receptor potential channel 3 2 Activities

Discover Target: TRPC3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPC6 Tchem Short transient receptor potential channel 6 2 Activities

Discover Target: TRPC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMAD3 Tchem Mothers against decapentaplegic homolog 3 0 Activities

Discover Target: SMAD3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

L3MBTL1 Tchem Lethal(3)malignant brain tumor-like protein 1 0 Activities

Discover Target: L3MBTL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B 0 Activities

Discover Target: BAZ2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Discover Target: TDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

Discover Target: APEX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GLP1R Tclin Glucagon-like peptide 1 receptor 0 Activities

Discover Target: GLP1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4A Tchem Lysine-specific demethylase 4A 0 Activities

Discover Target: KDM4A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-(4-methoxyphenyl)-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1,3-thiazol-2-amine
INCHI	InChI=1S/C20H19N3O2S/c1-25-17-8-6-16(7-9-17)21-20-22-18(13-26-20)19(24)23-11-10-14-4-2-3-5-15(14)12-23/h2-9,13H,10-12H2,1H3,(H,21,22)
InChi Key	NTXBDULODNTCKP-UHFFFAOYSA-N
Canonical SMILES	COc1ccc(cc1)Nc1scc(n1)C(=O)N1CCc2c(C1)cccc2
Isomeric SMILES	COC1=CC=C(C=C1)NC2=NC(=CS2)C(=O)N3CCC4=CC=CC=C4C3
PubChem CID	1096735

PubChem CID

1096735

ChEMBL Ligand

CHEMBL1506485

BindingDB Ligand

43434

References

1. Washburn DG, Holt DA, Dodson J, McAtee JJ, Terrell LR, Barton L, Manns S, Waszkiewicz A, Pritchard C, Gillie DJ et al.. (2013) The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore.. Bioorg Med Chem Lett, 23 (17): (4979-84). [PMID:23886683]

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