GTP-γ-S-Li4 - ≥90%, high purity , CAS No.94825-44-2

Item Number

G276049

Grouped product items
SKU	Size	Availability	Price
G276049-1mg	1mg	In stock	$61.90
G276049-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$213.90
G276049-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$270.90

G-protein-activating GTP analog

Basic Description

Synonyms	Gtp-gamma-S-tetralithium \| EINECS 305-606-1 \| tetralithium;[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] dioxidophosphinothioyl phosphate \| Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phos
Specifications & Purity	≥90%
Biochemical and Physiological Mechanisms	G-protein-activating GTP analog. More hydrolysis resistant than GTP. Stimulates insulin release from pancreatic β-cells. Inhibits organelle transport along axonal microtubules. Induces exocytosis in vivo.
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Names and Identifiers

Pubchem Sid	488202914
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488202914
IUPAC Name	tetralithium;[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] dioxidophosphinothioyl phosphate
INCHI	InChI=1S/C10H16N5O13P3S.4Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-29(19,20)27-30(21,22)28-31(23,24)32;;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H,21,22)(H2,23,24,32)(H3,11,13,14,18);;;;/q;4*+1/p-4/t3-,5-,6-,9-;;;;/m1..../s1
InChi Key	AMQXJFWJOAWCPV-ZVQJTLEUSA-J
Canonical SMILES	[Li+].[Li+].[Li+].[Li+].C1=NC2=C(N1C3C(C(C(O3)COP(=O)([O-])OP(=O)([O-])OP(=S)([O-])[O-])O)O)N=C(NC2=O)N
Isomeric SMILES	[Li+].[Li+].[Li+].[Li+].C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])OP(=O)([O-])OP(=S)([O-])[O-])O)O)N=C(NC2=O)N
WGK Germany	3
PubChem CID	135445735
Molecular Weight	567

Certificates

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10 results found

Lot Number	Certificate Type	Date	Item
E2310484	Certificate of Analysis	Feb 21, 2024	G276049
E2310485	Certificate of Analysis	Feb 21, 2024	G276049
E2310498	Certificate of Analysis	Jan 31, 2024	G276049
K2228549	Certificate of Analysis	Sep 21, 2023	G276049
K2228578	Certificate of Analysis	Sep 21, 2023	G276049
K2228601	Certificate of Analysis	Sep 21, 2023	G276049
I2122106	Certificate of Analysis	Apr 17, 2023	G276049
I2122193	Certificate of Analysis	Apr 17, 2023	G276049
I2122212	Certificate of Analysis	Jul 14, 2022	G276049
I2122213	Certificate of Analysis	Jul 14, 2022	G276049

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RIDADR	NONHforallmodesoftransport

References

1. Kutsch M et al.. (2020) Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions.. EMBO J, 39 (13): (e104926). [PMID:32510692]
2. Wandel MP et al.. (2020) Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms.. Nat Immunol, 21 (8): (880-891). [PMID:32541830]
3. Kovalski JR et al.. (2019) The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.. Mol Cell, 73 (4): (830-844.e12). [PMID:30639242]

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Basic Description