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GTS-21 , Neuronal acetylcholine receptor protein alpha-7 subunit agonist, CAS No.148372-04-7, Neuronal acetylcholine receptor protein alpha-7 subunit agonist

Moligand™

CAS#: 148372-04-7
Formula: C₁₉H₂₀N₂O₂
Molecular Weight: 308.37
PubChem CID: 5310985

Item Number

G610745

Grouped product items
SKU	Size	Availability	Price	Qty
G610745-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$922.90
G610745-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$4,000.90

View related series

nicotinic acetylcholine receptor α7 subunit Agonist

Basic Description

Synonyms	Gts-21\|148372-04-7\|3-(2,4-dimethoxybenzylidene)anabaseine\|DMXB-A\|Dimethoxybenzylidene anabaseine\|3-[(5E)-5-[(2,4-dimethoxyphenyl)methylidene]-3,4-dihydro-2H-pyridin-6-yl]pyridine\|8S399XDN2K\|CHEMBL134713\|3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Neuronal acetylcholine receptor protein alpha-7 subunit agonist

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRND Tclin Acetylcholine receptor subunit delta 0 Activities

Discover Target: CHRND

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRNA7 Tchem Neuronal acetylcholine receptor subunit alpha-7 3 Activities

Discover Target: CHRNA7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRNA3 Tclin Neuronal acetylcholine receptor subunit alpha-3 0 Activities

Discover Target: CHRNA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRNB2 Tclin Neuronal acetylcholine receptor subunit beta-2 0 Activities

Discover Target: CHRNB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRNB4 Tclin Neuronal acetylcholine receptor subunit beta-4 0 Activities

Discover Target: CHRNB4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-[(5E)-5-[(2,4-dimethoxyphenyl)methylidene]-3,4-dihydro-2H-pyridin-6-yl]pyridine
INCHI	InChI=1S/C19H20N2O2/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16/h3,6-9,11-13H,4-5,10H2,1-2H3/b15-11+
InChi Key	RPYWXZCFYPVCNQ-RVDMUPIBSA-N
Canonical SMILES	COC1=CC(=C(C=C1)C=C2CCCN=C2C3=CN=CC=C3)OC
Isomeric SMILES	COC1=CC(=C(C=C1)/C=C/2\CCCN=C2C3=CN=CC=C3)OC
PubChem CID	5310985
Molecular Weight	308.37

PubChem CID

RCSB PDB Ligand

CAS Registry No.

ChEMBL Ligand

References

1. Xie H, Yepuri N, Meng Q, Dhawan R, Leech CA, Chepurny OG, Holz GG, Cooney RN. (2020) Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation.. Rev Endocr Metab Disord, 21 (4): (431-447). [PMID:32851581]
2. Garg BK, Loring RH. (2019) GTS-21 has cell-specific anti-inflammatory effects independent of α7 nicotinic acetylcholine receptors.. PLoS One, 14 (4): (e0214942). [PMID:30947238]

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