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GTS-21 dihydrochloride (DMBX-A) - ≥98%, high purity , CAS No.156223-05-1

  • ≥98%
Item Number
G275216
Grouped product items
SKUSizeAvailabilityPrice Qty
G275216-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$58.90
G275216-10mg
10mg
In stock
$94.90
G275216-25mg
25mg
In stock
$136.90
G275216-50mg
50mg
In stock
$177.90
G275216-100mg
100mg
In stock
$276.90

α7 Nicotinic acetylcholine receptor agonist

Basic Description

SynonymsAKOS037515500 | SCHEMBL8003 | DMXB | DANSYLAMIDE [FOR FLUOROMETRY] | Gts 21 | GTS-21 2HCl | GTS-21 (dihydrochloride) | (E)-3-((2,4-Dimethoxyphenyl)methylene)-3,4,5,6-tetrahydro-2,3'-bipyridine dihydrochloride | 3-(3-(2,4-dimethoxybenzyl)-3,4,5,6-tetrahydr
Specifications & Purity≥98%
Biochemical and Physiological MechanismsPartial agonist at α7nACh receptors. Binds selectively to α7 subunits, with no significant activity seen at α2, α3 and α4. (EC 50 = 10 μM in vitro (striatal slices)). Shown to elicit nootropic, neuroprotective and anti-inflammatory effects.
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Names and Identifiers

Pubchem Sid504764180
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504764180
IUPAC Name 3-[(5E)-5-[(2,4-dimethoxyphenyl)methylidene]-3,4-dihydro-2H-pyridin-6-yl]pyridine;dihydrochloride
INCHI InChI=1S/C19H20N2O2.2ClH/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16;;/h3,6-9,11-13H,4-5,10H2,1-2H3;2*1H/b15-11+;;
InChi Key BXKYFUGAAFLYJL-BXGYHSFXSA-N
Canonical SMILES COC1=CC(=C(C=C1)C=C2CCCN=C2C3=CN=CC=C3)OC.Cl.Cl
Isomeric SMILES COC1=CC(=C(C=C1)/C=C/2\CCCN=C2C3=CN=CC=C3)OC.Cl.Cl
PubChem CID 6438361
Molecular Weight 381.3

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Enter lot number to search for analytical chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot NumberCertificate TypeDateItem
A2211791Certificate of AnalysisJul 12, 2023 G275216
A2211801Certificate of AnalysisJul 12, 2023 G275216
A2211844Certificate of AnalysisJul 12, 2023 G275216
A2211866Certificate of AnalysisJul 12, 2023 G275216
A2211871Certificate of AnalysisJul 12, 2023 G275216

Chemical and Physical Properties

SolubilitySoluble in water to 100 mM and in DMSO to 100 mM

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

Related Documents

References

1. Sun P et al..  (2017)  Deficiency of a7 nicotinic acetylcholine receptor attenuates bleomycin-induced lung fibrosis in mice..  Mol Med,  23    [PMID:28283678]
2. Xie DP et al..  (2020)  Effect of Electroacupuncture at Zusanli (ST36) on Sepsis Induced by Cecal Ligation Puncture and Its Relevance to Spleen..  Evid Based Complement Alternat Med,  2020  (1914031).  [PMID:33082818]
3. Zhao D et al..  (2017)  Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress..  J Neuroinflammation,  14  (234).  [PMID:29197398]
4. Sitapara RA et al..  (2020)  The a7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation..  Mol Med,  26  (63).  [PMID:32600307]
5. Chen X et al..  (2020)  Vagal-a7nAChR signaling promotes lung stem cells regeneration via fibroblast growth factor 10 during lung injury repair..  Stem Cell Res Ther,  11  (230).  [PMID:32522255]

Solution Calculators