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SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
G275216-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $58.90 | |
G275216-10mg | 10mg | In stock | $94.90 | |
G275216-25mg | 25mg | In stock | $136.90 | |
G275216-50mg | 50mg | In stock | $177.90 | |
G275216-100mg | 100mg | In stock | $276.90 |
α7 Nicotinic acetylcholine receptor agonist
Synonyms | AKOS037515500 | SCHEMBL8003 | DMXB | DANSYLAMIDE [FOR FLUOROMETRY] | Gts 21 | GTS-21 2HCl | GTS-21 (dihydrochloride) | (E)-3-((2,4-Dimethoxyphenyl)methylene)-3,4,5,6-tetrahydro-2,3'-bipyridine dihydrochloride | 3-(3-(2,4-dimethoxybenzyl)-3,4,5,6-tetrahydr |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Partial agonist at α7nACh receptors. Binds selectively to α7 subunits, with no significant activity seen at α2, α3 and α4. (EC 50 = 10 μM in vitro (striatal slices)). Shown to elicit nootropic, neuroprotective and anti-inflammatory effects. |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
Pubchem Sid | 504764180 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504764180 |
IUPAC Name | 3-[(5E)-5-[(2,4-dimethoxyphenyl)methylidene]-3,4-dihydro-2H-pyridin-6-yl]pyridine;dihydrochloride |
INCHI | InChI=1S/C19H20N2O2.2ClH/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16;;/h3,6-9,11-13H,4-5,10H2,1-2H3;2*1H/b15-11+;; |
InChi Key | BXKYFUGAAFLYJL-BXGYHSFXSA-N |
Canonical SMILES | COC1=CC(=C(C=C1)C=C2CCCN=C2C3=CN=CC=C3)OC.Cl.Cl |
Isomeric SMILES | COC1=CC(=C(C=C1)/C=C/2\CCCN=C2C3=CN=CC=C3)OC.Cl.Cl |
PubChem CID | 6438361 |
Molecular Weight | 381.3 |
Find and download the COA for your product by matching the lot number on the packaging.
5 results found
Lot Number | Certificate Type | Date | Item |
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Certificate of Analysis | Jul 12, 2023 | G275216 | |
Certificate of Analysis | Jul 12, 2023 | G275216 | |
Certificate of Analysis | Jul 12, 2023 | G275216 | |
Certificate of Analysis | Jul 12, 2023 | G275216 | |
Certificate of Analysis | Jul 12, 2023 | G275216 |
Solubility | Soluble in water to 100 mM and in DMSO to 100 mM |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. |
1. Sun P et al.. (2017) Deficiency of a7 nicotinic acetylcholine receptor attenuates bleomycin-induced lung fibrosis in mice.. Mol Med, 23 [PMID:28283678] |
2. Xie DP et al.. (2020) Effect of Electroacupuncture at Zusanli (ST36) on Sepsis Induced by Cecal Ligation Puncture and Its Relevance to Spleen.. Evid Based Complement Alternat Med, 2020 (1914031). [PMID:33082818] |
3. Zhao D et al.. (2017) Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress.. J Neuroinflammation, 14 (234). [PMID:29197398] |
4. Sitapara RA et al.. (2020) The a7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation.. Mol Med, 26 (63). [PMID:32600307] |
5. Chen X et al.. (2020) Vagal-a7nAChR signaling promotes lung stem cells regeneration via fibroblast growth factor 10 during lung injury repair.. Stem Cell Res Ther, 11 (230). [PMID:32522255] |