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GTS-21 dihydrochloride (DMBX-A) - ≥98%, high purity , CAS No.156223-05-1

≥98%

CAS#: 156223-05-1
Formula: C₁₉H₂₀N₂O_2·2HCl
Molecular Weight: 381.3
PubChem CID: 6438361

Item Number

G275216

Grouped product items
SKU	Size	Availability	Price
G275216-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$58.90
G275216-10mg	10mg	In stock	$94.90
G275216-25mg	25mg	In stock	$136.90
G275216-50mg	50mg	In stock	$177.90
G275216-100mg	100mg	In stock	$276.90

Discover GTS-21 dihydrochloride (DMBX-A) by Aladdin Scientific in ≥98% for only $58.90. Available - in Ligands at Aladdin Scientific. α7 Nicotinic acetylcholine receptor agonist Tags: .

Basic Description

Synonyms	GTS-21 dihydrochloride \| 156223-05-1 \| GTS 21 dihydrochloride \| GTS-21 (dihydrochloride) \| DMXBA \| 3-[(5E)-5-[(2,4-dimethoxyphenyl)methylidene]-3,4-dihydro-2H-pyridin-6-yl]pyridine;dihydrochloride \| DMBX-A \| DMBX-anabaseine \| (E)-3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetr
Specifications & Purity	≥98%
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Product Description	Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Names and Identifiers

IUPAC Name	3-[(5E)-5-[(2,4-dimethoxyphenyl)methylidene]-3,4-dihydro-2H-pyridin-6-yl]pyridine;dihydrochloride
INCHI	InChI=1S/C19H20N2O2.2ClH/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16;;/h3,6-9,11-13H,4-5,10H2,1-2H3;2*1H/b15-11+;;
InChi Key	BXKYFUGAAFLYJL-BXGYHSFXSA-N
Canonical SMILES	COC1=CC(=C(C=C1)C=C2CCCN=C2C3=CN=CC=C3)OC.Cl.Cl
Isomeric SMILES	COC1=CC(=C(C=C1)/C=C/2\CCCN=C2C3=CN=CC=C3)OC.Cl.Cl
PubChem CID	6438361
Molecular Weight	381.3

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
A2211791	Certificate of Analysis	Jul 12, 2023	G275216
A2211801	Certificate of Analysis	Jul 12, 2023	G275216
A2211844	Certificate of Analysis	Jul 12, 2023	G275216
A2211866	Certificate of Analysis	Jul 12, 2023	G275216
A2211871	Certificate of Analysis	Jul 12, 2023	G275216

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

References

1. Sun P et al.. (2017) Deficiency of a7 nicotinic acetylcholine receptor attenuates bleomycin-induced lung fibrosis in mice.. Mol Med, 23 [PMID:28283678]
2. Xie DP et al.. (2020) Effect of Electroacupuncture at Zusanli (ST36) on Sepsis Induced by Cecal Ligation Puncture and Its Relevance to Spleen.. Evid Based Complement Alternat Med, 2020 (1914031). [PMID:33082818]
3. Zhao D et al.. (2017) Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress.. J Neuroinflammation, 14 (234). [PMID:29197398]
4. Sitapara RA et al.. (2020) The a7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation.. Mol Med, 26 (63). [PMID:32600307]
5. Chen X et al.. (2020) Vagal-a7nAChR signaling promotes lung stem cells regeneration via fibroblast growth factor 10 during lung injury repair.. Stem Cell Res Ther, 11 (230). [PMID:32522255]

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