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Guanfacine - 98%, high purity , CAS No.29110-47-2, Agonist of α 2A-adrenoceptor;Agonist of α 2B-adrenoceptor;Agonist of α 2C-adrenoceptor
Basic Description
| Synonyms | GUANFACINE|29110-47-2|Estulic|Guanfacinum [INN-Latin]|Guanfacina [INN-Spanish]|Guanfacinum|Guanfacina|Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-|N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide|N-amidino-2-(2,6-dichlorophenyl)acetamide|UNI |
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| Specifications & Purity | Moligand™, ≥98% |
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| Storage Temp | Store at -20°C |
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| Shipped In | Ice chest + Ice pads |
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| Grade | Moligand™ |
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| Action Type | AGONIST |
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| Mechanism of action | Agonist of α 2A-adrenoceptor;Agonist of α 2B-adrenoceptor;Agonist of α 2C-adrenoceptor |
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| Product Description | Guanfacine is an activator of α2A-AR. |
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Product Properties
| pKa | pKₐ: 5.29 (Predicted) |
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| Ki Data | Alpha-2a adrenergic receptor: Ki= 50 nM (human); Serotonin 2c (5-HT2c) receptor: Ki= 761 nM (human); Alpha-2c adrenergic receptor: Ki= 937 nM (human); Serotonin 2b (5-HT2b) receptor: Ki= 1335 nM (human) |
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Names and Identifiers
| IUPAC Name | N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide |
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| INCHI | InChI=1S/C9H9Cl2N3O/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13/h1-3H,4H2,(H4,12,13,14,15) |
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| InChi Key | INJOMKTZOLKMBF-UHFFFAOYSA-N |
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| Canonical SMILES | C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl |
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| Isomeric SMILES | C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl |
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| RTECS | CY1481000 |
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| PubChem CID | 3519 |
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| Molecular Weight | 246.09 |
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Chemical and Physical Properties
| Solubility | Soluble in methanol, DMSO, and water (1.89 mg/ml). |
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| Refractive Index | n20D1.64 (Predicted) |
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| Melt Point(°C) | 226° C |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS06 |
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| Signal | Danger |
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| Hazard Statements | H301:Toxic if swallowed |
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| Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. |
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| RTECS | CY1481000 |
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