Guanidine thiocyanate solution

Item Number
G755743
Grouped product items
SKUSizeAvailabilityPrice Qty
G755743-50ml
50ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$121.90
G755743-250ml
250ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$408.90

Basic Description

Specifications & PurityBioUltra, for molecular biology, ~6 M in H2O
Storage TempRoom temperature
Shipped InNormal
GradeBioUltra, for molecular biology
Product Description

Guanidine thiocyanate is a chaotropic agent that functions as a strong protein denaturant. It is widely used in RNA isolation protocols. Guanidine thiocyanate can irreversibly inactivate RNase and DNase and breaks cellular membranes. It dissolves proteins by disturbing their secondary structures. Guanidine thiocyanate also separates nucleoproteins from nucleic acids and aids the digestion of the proteins with proteases. It improves the activity of proteinase K thus making it the protease of choice.
Application:
Guanidine thiocyanate solution has been used to extract:
  • plasma RNA from human immunodeficiency virus (HIV)-infected and control patients
  • total RNA from collected tissues (shoots, flowers, fruits, and seeds)
  • in reverse transcription-polymerase chain reaction (RT-PCR) analysis, RNA from teratocarcinoma cell line (Tera-1)

Names and Identifiers

PH4.5-7.0 (25 °C)
IUPAC Name guanidine;thiocyanic acid
INCHI InChI=1S/CH5N3.CHNS/c2-1(3)4;2-1-3/h(H5,2,3,4);3H
InChi Key ZJYYHGLJYGJLLN-UHFFFAOYSA-N
Canonical SMILES C(#N)S.C(=N)(N)N
Isomeric SMILES C(#N)S.C(=N)(N)N
WGK Germany 2
RTECS XL1225000
PubChem CID 65046
UN Number 1759
Packing Group III
Molecular Weight 118.16
Beilstein 3563461
Reaxy-Rn 3563461

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

Melt Point(°C)118-122°C

Safety and Hazards(GHS)

Pictogram(s) GHS05,   GHS07
Signal Danger
Hazard Statements

H314:Causes severe skin burns and eye damage

H412:Harmful to aquatic life with long lasting effects

H302:Harmful if swallowed

H318:Causes serious eye damage

H312:Harmful in contact with skin

H332:Harmful if inhaled

H302+H312+H332:Harmful if swallowed, in contact with skin or if inhaled

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P363:Wash contaminated clothing before reuse.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.

P317:Get emergency medical help.

P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes.

P316:Get emergency medical help immediately.

WGK Germany 2
RTECS XL1225000
Reaxy-Rn 3563461
Class 8

Related Documents

Solution Calculators