Guanosine 3',5'-cyclic monophosphate sodium salt (cGMP) - ≥99%, high purity , CAS No.40732-48-7

Item Number

G276529

Grouped product items
SKU	Size	Availability	Price	Qty
G276529-25mg	25mg	2	$38.90	+-
G276529-100mg	100mg	2	$128.90	+-

Cyclic nucleotide second messenger

Basic Description

Synonyms	BDBM11316 \| Guanosine Monophosphate Monosodium Salt \| Q27265640 \| 6WYT1TNR45 \| Guanosine-3':5'-cyclic monophosphate monosodium salt \| MFCD00038424 \| GUANOSINE3:5-CYCLICMONOPHOSPHATESODIUMSALT \| GUANOSINE, CYCLIC 3',5'-(HYDROGEN PHOSPHATE), SODIUM SALT (1:
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	An important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-re
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Names and Identifiers

Pubchem Sid	504773327
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504773327
IUPAC Name	sodium;9-[(4aR,6R,7R,7aS)-7-hydroxy-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-1H-purin-6-one
INCHI	InChI=1S/C10H12N5O7P.Na/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
InChi Key	KMPIYXNEROUNOG-GWTDSMLYSA-M
Canonical SMILES	C1C2C(C(C(O2)N3C=NC4=C3N=C(NC4=O)N)O)OP(=O)(O1)[O-].[Na+]
Isomeric SMILES	C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C3N=C(NC4=O)N)O)OP(=O)(O1)[O-].[Na+]
PubChem CID	135445730
Molecular Weight	367.19

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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8 results found

Lot Number	Certificate Type	Date	Item
G2404014	Certificate of Analysis	Jul 13, 2024	G276529
F23061201	Certificate of Analysis	May 09, 2024	G276529
F23061186	Certificate of Analysis	May 09, 2024	G276529
F23061184	Certificate of Analysis	Mar 21, 2024	G276529
L2315061	Certificate of Analysis	Mar 10, 2023	G276529
K2110402	Certificate of Analysis	Sep 09, 2022	G276529
G2228474	Certificate of Analysis	Jun 20, 2022	G276529
G2228505	Certificate of Analysis	Jun 20, 2022	G276529

Chemical and Physical Properties

Solubility	Soluble in water to 100 mM
Molecular Weight	367.190 g/mol
XLogP3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	1
Exact Mass	367.029 Da
Monoisotopic Mass	367.029 Da
Topological Polar Surface Area	173.000 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	622.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Citations of This Product(1)

1. Ma Yufeng, Zhang Fengsen, Zhong Yijing, Huang Yongchun, Yixizhuoma , Jia Qiangqiang, Zhang Shoude. (2023) A label-free LC/MS-based enzymatic activity assay for the detection of PDE5A inhibitors. Frontiers in Chemistry, 11 [PMID:36860644] [10.3389/fchem.2023.1097027]

References

1. Feil R et al.. (2005) Function of cGMP-dependent protein kinases in the nervous system.. Rev Neurosci, 16 (23-41). [PMID:15810652]
2. Krumenacker JS & Murad F. (2006) NO-cGMP signaling in development and stem cells.. Mol Genet Metab, 87 (4): (311-4). [PMID:16356747]
3. Davies SA. (2006) Signalling via cGMP: lessons from Drosophila.. Cell Signal, 18 (4): (409-21). [PMID:16260119]
4. Ma Yufeng, Zhang Fengsen, Zhong Yijing, Huang Yongchun, Yixizhuoma , Jia Qiangqiang, Zhang Shoude. (2023) A label-free LC/MS-based enzymatic activity assay for the detection of PDE5A inhibitors. Frontiers in Chemistry, 11 [PMID:36860644] [10.3389/fchem.2023.1097027]

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Basic Description